| 68401 | Gzmk | granzyme K | ENCODES a protein that exhibits serine-type peptidase activity; glycosaminoglycan binding (ortholog); pattern recognition receptor activity (ortholog); INVOLVED IN complement activation, GZMK pathway (ortholog); opsonization (ortholog); positive regulation of in flammatory response (ortholog); FOUND IN extracellular space (ortholog); symbiont cell surface (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 46573997 | 46582015 | Rat | 105 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 620005 | C4a | complement C4A (Rodgers blood group) | ENCODES a protein that exhibits antigen binding (ortholog); complement component C1q complex binding (ortholog); INVOLVED IN complement activation (ortholog); complement activation, classical pathway (ortholog); complement activation, GZMK pathway (ortholog); PA RTICIPATES IN classical complement pathway; ASSOCIATED WITH complement component 4A deficiency (ortholog); genetic disease (ortholog); Graves' disease (ortholog); FOUND IN extracellular region; extracellular space; axon (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 20 | 4010306 | 4024707 | Rat | 140 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1591983 | C4b | complement C4B | ENCODES a protein that exhibits antigen binding (ortholog); carbohydrate binding (ortholog); complement binding (ortholog); INVOLVED IN complement activation (ortholog); complement activation, classical pathway (ortholog); complement activation, GZMK pathway (or tholog); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; ASSOCIATED WITH autistic disorder (ortholog); autoimmune disease (ortholog); complement component 4B deficiency (ortholog); FOUND IN extracellular region; extracellular space; axon (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 20 | 4201979 | 4216292 | Rat | 214 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2238 | C6 | complement C6 | ENCODES a protein that exhibits wide pore channel activity (ortholog); INVOLVED IN positive regulation of apoptotic process; complement activation (ortholog); complement activation, GZMK pathway (ortholog); PARTICIPATES IN coagulation cascade pathway; complement system pathway; prion disease pathway; ASSOCIATED WITH decreased susceptibility to experimental autoimmune myasthenia gravis; ASSOCIATED WITH alcohol-associated liver disease; end stage renal disease; Experimental Autoimmune Encephalomyelitis; FOUND IN extracellular space; membrane attack complex (ortholog); other organism cell membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 55573596 | 55648857 | Rat | 193 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620318 | C7 | complement C7 | ENCODES a protein that exhibits wide pore channel activity (ortholog); INVOLVED IN intracellular sodium ion homeostasis; complement activation (ortholog); complement activation, GZMK pathway (ortholog); PARTICIPATES IN coagulation cascade pathway; complement sys tem pathway; prion disease pathway; ASSOCIATED WITH Experimental Seizures; membranous glomerulonephritis; myocardial infarction; FOUND IN membrane attack complex (ortholog); other organism cell membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 1-nitropropane; 17beta-estradiol | 2 | 55815687 | 55892605 | Rat | 131 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1308355 | C8a | complement C8 alpha chain | ENCODES a protein that exhibits complement binding; protein-containing complex binding; wide pore channel activity (ortholog); INVOLVED IN complement activation (ortholog); complement activation, GZMK pathway (ortholog); killing of cells of another organism (ort holog); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Entamoebiasis pathway; ASSOCIATED WITH myocardial infarction; meningitis (ortholog); Neisseriaceae Infections (ortholog); FOUND IN extracellular region; extracellular space; membrane attack complex (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene | 5 | 124812131 | 124866631 | Rat | 139 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 2239 | C8b | complement C8 beta chain | ENCODES a protein that exhibits protein-containing complex binding; wide pore channel activity (ortholog); INVOLVED IN complement activation (ortholog); complement activation, GZMK pathway (ortholog); killing of cells of another organism (ortholog); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Entamoebiasis pathway; ASSOCIATED WITH myocardial infarction; complement component 6 deficiency (ortholog); genetic disease (ortholog); FOUND IN extracellular region; extracellular space; membrane attack complex (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole | 5 | 124763974 | 124801522 | Rat | 149 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1309074 | C8g | complement C8 gamma chain | ENCODES a protein that exhibits complement binding; protein-containing complex binding; wide pore channel activity (ortholog); INVOLVED IN complement activation (ortholog); complement activation, GZMK pathway (ortholog); killing of cells of another organism (ort holog); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Entamoebiasis pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extracellular region; extracellular space; membrane attack complex (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 28718648 | 28720232 | Rat | 113 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620319 | C9 | complement C9 | ENCODES a protein that exhibits wide pore channel activity (ortholog); INVOLVED IN cell killing (ortholog); complement activation (ortholog); complement activation, GZMK pathway (ortholog); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Entamoebiasis pathway; ASSOCIATED WITH polycystic kidney disease; age related macular degeneration 15 (ortholog); autosomal dominant polycystic kidney disease (ortholog); FOUND IN extracellular space (ortholog); membrane attack complex (ortholog); other organism cell membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 57300510 | 57348759 | Rat | 189 | description | gene, protein-coding, PROVISIONAL [RefSeq] |