glutamate ionotropic receptor NMDA type subunit 2A
ENCODES a protein that exhibits ATPase binding; calcium-dependent protein binding; cell adhesion molecule binding; INVOLVED IN action potential; auditory behavior; cellular response to amino acid stimulus; PARTICIPATES IN excitatory synaptic transmission pathway; long term depression; long term pote
ntiation; ASSOCIATED WITH abnormal drug-induced reinstatement of an extinguished operant behavior for a drug reinforcer; increased susceptibility to ischemic brain injury; ASSOCIATED WITH alcohol use disorder; Brain Hypoxia-Ischemia; Central Nervous System Viral Diseases; FOUND IN cell surface; cytoplasm; dendrite membrane; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; (R)-lipoic acid
This allele has a deletion of a 1065bp region spanning Grin2a exon 8 (which encodes key pore forming domains of GluN2A) in Long Evans (LE) embryos, generating a KO allele.