ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN negative regulation of non-canonical NF-kappaB signal transduction (ortholog); positive regulation
of canonical NF-kappaB signal transduction (ortholog); positive regulation of circadian rhythm (ortholog); PARTICIPATES IN Hedgehog signaling pathway; mTOR signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH NEURODEVELOPMENTAL, JAW, EYE, AND DIGITAL SYNDROME (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride