ENCODES a protein that exhibits kinesin binding; protein-containing complex binding; identical protein binding (ortholog); INVOLVED IN cilium assembly; nervous system development; positive regulation of axon extension; ASSOCIATED WITH anxiety disorder (ortholog); Asperger syndrome (ortholog); autist
CRISPR/Cas9 system was used to introduce a 371-bp deletion of exon 2 in the rat Disc1 gene of one-cell Crl:SD embryos. This deletion caused non-sense mutation and early termination of translation.
INVOLVED IN brain development (ortholog); centrosome localization (ortholog); cerebral cortex radially oriented cell migration (ortholog); ASSOCIATED WITH disorder of sexual development (ortholog); hypogonadotropic hypogonadism (ortholog); hypogonadotropic hypogonadism 7 with or without anosmia (ort