| 1308190 | Cul3 | cullin 3 | ENCODES a protein that exhibits cyclin binding (ortholog); identical protein binding (ortholog); Notch binding (ortholog); INVOLVED IN anaphase-promoting complex-dependent catabolic process (ortholog); cell migration (ortholog); cell morphogenesis (ortholog); PARTICIPATES IN neddylation pathway; nuc lear factor, erythroid 2 like 2 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant pseudohypoaldosteronism type 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN centrosome (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 9 | 89040987 | 89118775 | Rat | 320 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 628717 | Klhl12 | kelch-like family member 12 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN COPII vesicle coating (ortholog); endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); neural crest cell development (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; FOUND IN COPII vesicle coat (ortholog); COPII-coated ER to Golgi transport vesicle (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 48451920 | 48485638 | Rat | 100 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1591979 | Kctd10 | potassium channel tetramerization domain containing 10 | ENCODES a protein that exhibits identical protein binding (ortholog); Notch binding (ortholog); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); negative regulation of Notch signaling pathway (ortholog); FOUND IN Cul3-RING ubiquitin ligase comp lex (ortholog); MKS complex (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil | 12 | 47890777 | 47909391 | Rat | 95 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735189 | Kctd13 | potassium channel tetramerization domain containing 13 | ENCODES a protein that exhibits protein domain specific binding; identical protein binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN positive regulation of DNA replication; cell migration (ortholog); negative regulation of Rho protein signal transduction (o rtholog); ASSOCIATED WITH autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); spondylocostal dysostosis 5 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); nuclear body (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione | 1 | 190965073 | 190983381 | Rat | 89 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 3877 | Tnfaip1 | TNF alpha induced protein 1 | ENCODES a protein that exhibits cyclin binding; identical protein binding (ortholog); small GTPase binding (ortholog); INVOLVED IN positive regulation of DNA replication; cell migration (ortholog); immune response (ortholog); ASSOCIATED WITH Diabetic Nephropathies (ortholog); FOUND IN Cul3 ont-weight:700;'>Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); endosome (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 10 | 63915824 | 63930514 | Rat | 118 | old_gene_name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1308131 | Arih1 | ariadne RBR E3 ubiquitin protein ligase 1 | ENCODES a protein that exhibits ubiquitin conjugating enzyme binding (ortholog); ubiquitin protein ligase binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH ao rtic aneurysm (ortholog); Marfan syndrome (ortholog); thoracic aortic aneurysm (ortholog); FOUND IN Cul2-RING ubiquitin ligase complex (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); Cul4A-RING E3 ubiquitin ligase complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 8 | 68673199 | 68775648 | Rat | 126 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1306553 | Armc5 | armadillo repeat containing 5 | ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN adrenal cortex development (ortholog); CD4-positive, alpha-beta T cell differentiation (ortholog); defense response to virus (ortholog); ASSOCIATED W ITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); ACTH-independent macronodular adrenal hyperplasia 2 (ortholog); genetic disease (ortholog); FOUND IN chromatin (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,4-methylenedioxymethamphetamine | 1 | 192250580 | 192257347 | Rat | 86 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1311535 | Depdc5 | DEP domain containing 5, GATOR1 subcomplex subunit | ENCODES a protein that exhibits protein-containing complex binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to amino acid starvation (ortholog); negative regulation of TORC1 signaling (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH abnormal after hyperpolarization; abnormal lateral ventricle morphology; abnormal neocortex morphology; ASSOCIATED WITH autosomal dominant nocturnal frontal lobe epilepsy (ortholog); benign epilepsy with centrotemporal spikes (ortholog); Developmental and Epileptic Encephalopathy 111 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytosol (ortholog); GATOR1 complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A | 14 | 81956777 | 82087392 | Rat | 117 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1307766 | Gan | gigaxonin | INVOLVED IN protein ubiquitination (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); genetic disease (ortholog); Giant Axonal Neuropathy (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); microtubule cytos keleton (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide | 19 | 62116600 | 62173879 | Rat | 79 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1588600 | Glmn | glomulin, FKBP associated protein | ENCODES a protein that exhibits hepatocyte growth factor receptor binding (ortholog); signaling receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); circulatory system development (ortholog); epigenetic regulation o f gene expression (ortholog); ASSOCIATED WITH arteriovenous malformation (ortholog); Blue Rubber Bleb Nevus Syndrome (ortholog); familial glomangioma (ortholog); FOUND IN Cul2-RING ubiquitin ligase complex (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); Cul4A-RING E3 ubiquitin ligase complex (ortholog); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; bisphenol A | 14 | 2332052 | 2375366 | Rat | 92 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1305086 | Kbtbd6 | kelch repeat and BTB domain containing 6 | INVOLVED IN proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); protein K48-linked ubiquitination (ortholog); regulation of Rac protein signal transduction (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (o rtholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan | 15 | 61257360 | 61259117 | Rat | 61 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 6501695 | Kbtbd7 | kelch repeat and BTB domain containing 7 | INVOLVED IN proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); protein K48-linked ubiquitination (ortholog); regulation of Rac protein signal transduction (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WI TH bisphenol A; trichloroethene; 1,2-dimethylhydrazine (ortholog) | 15 | 61215957 | 61220536 | Rat | 55 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1563166 | Kbtbd8 | kelch repeat and BTB domain containing 8 | INVOLVED IN neural crest cell development (ortholog); neural crest formation (ortholog); protein monoubiquitination (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; allethrin | 4 | 129232781 | 129245608 | Rat | 112 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1311154 | Kctd17 | potassium channel tetramerization domain containing 17 | ENCODES a protein that exhibits cullin family protein binding (ortholog); identical protein binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN endoplasmic reticulum calcium ion homeostasis (ortholog); positive regulation of cilium assembly (ortholog); protea some-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); myoclonic dystonia (ortholog); myoclonic dystonia 26 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH bisphenol A; Cuprizon; (1->4)-beta-D-glucan (ortholog) | 7 | 111859556 | 111891869 | Rat | 76 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1559646 | Klhl13 | kelch-like family member 13 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); regulation of cytokinesis (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | X | 118747298 | 118912279 | Rat | 114 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1563101 | Klhl15 | kelch-like family member 15 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN negative regulation of double-strand break repair via homologous recombination (ortholog); nuclear protein quality control by the ubiquitin-proteasome system (ortholog); ubiquitin-dependent prote in catabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); non-syndromic X-linked intellectual disability 103 (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A | X | 62987762 | 63043980 | Rat | 87 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1306388 | Klhl2 | kelch-like family member 2 | ENCODES a protein that exhibits actin binding (ortholog); identical protein binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); FOUND IN actin cytoskeleton (ortholog); Cul3-RING ubiquiti n ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 16 | 29627171 | 29739782 | Rat | 99 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1309490 | Klhl20 | kelch-like family member 20 | ENCODES a protein that exhibits type II interferon binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN Golgi to endosome transport (ortholog); negative regulation of apoptotic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (orthol og); PARTICIPATES IN E-cadherin signaling pathway; ASSOCIATED WITH intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); prostate cancer (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride | 13 | 75896802 | 75941724 | Rat | 96 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1305863 | Klhl21 | kelch-like family member 21 | ENCODES a protein that exhibits cullin family protein binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN chromosome passenger complex localization to spindle midzone (ortholog); protein ubiquitination (ortholog); regulation of cytokinesis (ortholog); ASSOCIATED WITH E pendymomas (ortholog); FOUND IN centrosome (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); polar microtubule (ortholog); INTERACTS WITH aflatoxin B1; bisphenol A; C60 fullerene | 5 | 167797621 | 167806276 | Rat | 153 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306288 | Klhl22 | kelch-like family member 22 | ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN cell division (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to L-leucine (ortholog); FOUND IN centrosome (ortholog); Cul3 style='font-weight:700;'>Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 11 | 96695168 | 96736079 | Rat | 128 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 727971 | Klhl24 | kelch-like family member 24 | INVOLVED IN intermediate filament organization (ortholog); protein autoubiquitination (ortholog); protein ubiquitination (ortholog); ASSOCIATED WITH cardiomyopathy (ortholog); epidermolysis bullosa simplex generalized type (ortholog); Generalized Epidermolysis Bullosa Simplex 6 with Scarring and Hai r Loss (ortholog); FOUND IN adherens junction (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 11 | 94348024 | 94382085 | Rat | 228 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1310815 | Klhl25 | kelch-like family member 25 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN negative regulation of fatty acid biosynthetic process (ortholog); positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (ortholog); positive regulation of fatty acid oxidation (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; acrylamide | 1 | 139134655 | 139159898 | Rat | 86 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1565218 | Klhl3 | kelch-like family member 3 | ENCODES a protein that exhibits cullin family protein binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN distal tubule morphogenesis (ortholog); gene expression (ortholog); monoatomic ion homeostasis (ortholog); ASSOCIATED WITH autosomal dominant pseudohypoa ldosteronism type 1 (ortholog); cerebral palsy (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl | 17 | 6528114 | 6651338 | Rat | 120 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1305368 | Klhl40 | kelch-like family member 40 | INVOLVED IN negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); negative regulation of protein ubiquitination (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); nemaline myopathy 8 (ortholog); FOUND IN A band (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; alpha-Zearalanol | 8 | 130318793 | 130324309 | Rat | 66 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 620852 | Klhl41 | kelch-like family member 41 | INVOLVED IN pseudopodium assembly; myofibril assembly (ortholog); protein ubiquitination (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypertrophic cardiomyopathy (ortholog); nemaline myopathy (ortholog); FOUND IN pseudopodium; Cul3-RING ubiquitin liga se complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 3 | 74842118 | 74855244 | Rat | 121 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1560924 | Klhl42 | kelch-like family, member 42 | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); protein polyubiquitination (ortholog); regulation of microtubule-based process (ortholog); FOUND IN Cul3 0;'>Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine | 4 | 181730343 | 181760899 | Rat | 85 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1305564 | Klhl7 | kelch-like family member 7 | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ASSOCIATED WITH Bohring Syndrome (ortholog); cold-induced sweating syndrome (ortholog); cold-induced sweating syndrome 1 (ortholog); FOUN D IN Cul3-RING ubiquitin ligase complex (ortholog); cytosol (ortholog); nucleolus (ortholog); INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; benzo[a]pyrene | 4 | 11898766 | 11947796 | Rat | 118 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1304685 | Klhl8 | kelch-like family member 8 | INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH catecholaminergic polymorphic ventricular tachycardia (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); nucleoplasm (orthol og); INTERACTS WITH 2,6-dinitrotoluene; acetamide; amphetamine | 14 | 6112472 | 6158001 | Rat | 50 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1304814 | Klhl9 | kelch-like family member 9 | ENCODES a protein that exhibits cullin family protein binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); regulation of cytokinesis (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); midbody (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A | 5 | 108449492 | 108453676 | Rat | 88 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1309100 | Lztr1 | leucine zipper like post translational regulator 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN negative regulation of Ras protein signal transduction (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); protein ubiquitin ation (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); bladder exstrophy (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); endomembrane system (ortholog); Golgi apparatus (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; endosulfan; methimazole | 11 | 96991956 | 97008127 | Rat | 123 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1311239 | Pdcd6 | programmed cell death 6 | ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to heat (ortholog); COPII vesicle coating (ortholog); FOUND IN COPII vesicle coat (ortholog) ; Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol | 1 | 30795105 | 30810771 | Rat | 203 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1359536 | Pef1 | penta-EF hand domain containing 1 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); identical protein binding (ortholog); protein dimerization activity (ortholog); INVOLVED IN COPII vesicle coating (ortholog); endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); neural crest cell developm ent (ortholog); FOUND IN COPII vesicle coat (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene | 5 | 147735973 | 147759239 | Rat | 106 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1308453 | Rbx1 | ring-box 1 | ENCODES a protein that exhibits protein-containing complex binding; cullin family protein binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to oxidative stress (ortholog); cellular response to UV (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; neddylation pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH Rubinstein-Taybi syndrome (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN VCB complex; Cul2-RING ubiquitin ligase complex (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 7 | 114870893 | 114881194 | Rat | 243 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1309924 | Rhobtb2 | Rho-related BTB domain containing 2 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 64 (ortholog); dystonia (ortholog); genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WITH (+)-schisandrin B; 1-nitropropane; 2,3,7,8-tetrachlorodibenzodioxine | 15 | 51278024 | 51298209 | Rat | 121 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1311613 | Spop | speckle type BTB/POZ protein | ENCODES a protein that exhibits identical protein binding (ortholog); molecular function inhibitor activity (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN glucose homeostasis (ortholog); negative regulation of transcription by RNA polymerase I I (ortholog); obsolete negative regulation of DNA-binding transcription factor activity (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); Ductal Carcinoma (ortholog); Endometrial Neoplasms (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); nuclear speck (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A | 10 | 80854890 | 80935781 | Rat | 106 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1305847 | Spopl | speckle type BTB/POZ protein like | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 3 | 26478535 | 26552344 | Rat | 67 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1309414 | Zswim8 | zinc finger, SWIM-type containing 8 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN positive regulation of miRNA catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); protein quality control for misfolded or incompletely synt hesized proteins (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (ortholog); cullin-RING ubiquitin ligase complex (ortholog); cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; 4,4'-sulfonyldiphenol; bisphenol A | 15 | 3623040 | 3638748 | Rat | 72 | description | gene, protein-coding, VALIDATED [RefSeq] |