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Strain Registration

Strain: LEW-Tg(HLA-B*2705m1,B2M)133-1TrgTg/Tg

Symbol: LEW-Tg(HLA-B*2705m1,B2M)133-1TrgTg/Tg
Strain: LEW-Tg(HLA-B*2705m1,B2M)133-1Trg homozygous rat
RGD ID: 738120
Citation ID: RRID:RRRC_00043
Ontology ID: RS:0000490
Also Known As: HLA-B27 transgenic rat; Line133-1; LEW-Tg(HLA-B*2705m1,B2M)133-1Trg; LEW-Tg(HLA-B*2705m1,B2M)133-1Trg^[Tg/Tg]
Type: transgenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: This strain was made by pronuclear injection into Lewis embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene (human HLA-B27 gene with Serine replacing Cys67) and the human beta-2-microglobulin gene. Founder 133-1 was selected and carrier animals from this founder were mated and bred to homozygosity. The strain was transferred from Dr. Joel Taurog, University of Texas Southwestern Medical School in Dallas to the Rat Resource and Research Center in 2002. The strain has been maintained by sibling mating.
Genetic Status: Homozygous
Coat Color: Albino
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-11-20)





Disease Annotations     Click to see Annotation Detail View
arthritis  (IAGP)
colitis  (IAGP)
orchitis  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
arthritis  (IAGP)
colitis  (IAGP)
testis inflammation  (IAGP)

References

References - curated
# Reference Title Reference Citation
1. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Inflammatory disease in HLA-B27 transgenic rats. Taurog JD, etal., Immunol Rev 1999 Jun;169:209-23.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This strain develops arthritis and an inflammatory colitis in homozygous rats around 8 months of age. Orchitis develops in both the hemizygous and homozygous males at an early age. Homozygous male rats are sterile by 4 months of age. 731214
strain_life_disease In human the B27 gene product is responsible for spondyloarthropathies suggesting this molecule may contribute to B27-associated disease susceptibility. 731214
strain_reproduction Average gestation period is 22 days with an average of 10 pups per litter. Homozygous males become sterile by 4 months of age. 731214

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-08 LEW-Tg(HLA-B*2705m1,B2M)133-1TrgTg/Tg    LEW-Tg(HLA-B*2705m1,B2M)133-1Trg    Symbol and/or name change 68913 APPROVED
2012-04-18 LEW-Tg(HLA-B*2705m1,B2M)133-1Trg    LEW-Tg(HLA-B*2705m1,B2M)133-1Trg    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00043 RGD