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Strain Registration

Strain: LEW-Tg(HLA-B*0702,B2M)120-4TrgTg/Tg

Symbol: LEW-Tg(HLA-B*0702,B2M)120-4TrgTg/Tg
Strain: LEW-Tg(HLA-B*0702,B2M)120-4Trg homozygous rat
RGD ID: 737703
Citation ID: RRID:RRRC_00042
Ontology ID: RS:0000489
Also Known As: LEW-Tg(HLA-B*0702,B2M)120-4Trg; LEW-Tg(HLA-B*0702,B2M)120-4Trg^[Tg/Tg]
Type: transgenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: Lewis from CRL were used as the background strain. This strain was made by pronuclear injection into Lewis embryos. The embryos were coinjected with DNA fragments containing the HLA-B*0702 human gene and the human beta-2-microglobulin gene. Founder 120-4 was selected and carrier animals from this founder were mated and this strain was bred to homozygosity.
Genetic Status: Homozygous
Coat Color: Albino
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2020-07-08)






References

References - curated
# Reference Title Reference Citation
1. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Inflammatory disease in HLA-B27 transgenic rats. Taurog JD, etal., Immunol Rev 1999 Jun;169:209-23.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These animals are normal and healthy. This strain serves as the control strain for the HLA B27 transgenic rats which develop autoimmune arthritis, the HLA B7 transgene is not associated with any phenotype. Hemizygous animals have the highest copy number of the HLA-B7 locus (26) whereas the copy number of human B2M is low (5). 731214
strain_life_disease In human the B27 gene product is responsible for spondyloarthropathies suggesting this molecule may contribute to B27-associated disease susceptibility. 731214
strain_reproduction Average gestation period is 22 days with an average of 10 pups per litter. 731214

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-08 LEW-Tg(HLA-B*0702,B2M)120-4TrgTg/Tg    LEW-Tg(HLA-B*0702,B2M)120-4Trg    Symbol and/or name change 68913 APPROVED
2012-04-18 LEW-Tg(HLA-B*0702,B2M)120-4Trg    LEW-Tg(HLA-B*0702,B2M)120-4Trg    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00042 RGD