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Strain Registration

Strain: SHRSP/Gcrc

Symbol: SHRSP/Gcrc
Strain: SHRSP
Substrain: Gcrc
Full Name: Spontaneously hypertensive rat, stroke prone
RGD ID: 734759
Citation ID: RRID:RGD_734759
Ontology ID: RS:0000760
Also Known As: SHRSP/Gla; C2773; MDC-03-22
Type: inbred
Available Source: Not Available
Origination: University of Glasgow, Western Infirmary, Glasgow, UK
Description: SHRSP strain is maintained at the University of Glasgow since December 1991. This colony is the result of the strain specific brother-sister mating of 13 SHRSP (6 males and 7 females of each) that were obtained from Dr D.F. Bohr (Department of Physiology, University of Michigan, Ann Arbor) where they had been maintained as inbred colonies for more than 15 years. Their breeding stocks were originally obtained from NIH
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Genetic and gender influences on sensitivity to focal cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Carswell HV, etal., Hypertension. 1999 Feb;33(2):681-5. doi: 10.1161/01.hyp.33.2.681.
2. Quantitative trait loci in genetically hypertensive rats. Possible sex specificity. Clark JS, etal., Hypertension 1996 Nov;28(5):898-906
3. The genetics of cardiovascular disease. Delles C, etal., Trends Endocrinol Metab. 2008 Sep 24.
4. Candidate Genes That Determine Response to Salt in the Stroke-Prone Spontaneously Hypertensive Rat. Congenic Analysis. Graham D, etal., Hypertension. 2007 Oct 15;.
5. Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2. Jeffs B, etal., Hypertension 2000 Jan;35(1 Pt 2):179-87.
6. Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Jeffs B, etal., Nat Genet 1997 Aug;16(4):364-7
7. Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3. Koh-Tan HH, etal., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155.
8. Microarray analysis of rat chromosome 2 congenic strains. McBride MW, etal., Hypertension 2003 Mar;41(3 Pt 2):847-53.
9. Differences in the Evolution of the Ischemic Penumbra in Stroke-Prone Spontaneously Hypertensive and Wistar-Kyoto Rats. McCabe C, etal., Stroke. 2009 Sep 24.
10. RGD Strain RSO annotation pipeline RGD Automated Pipelines
11. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

Region

Strain QTL Data
Symbol Name Trait
Bp13 Blood pressure QTL 13 blood pressure trait   (VT:0000183)    
Bp14 Blood pressure QTL 14 arterial blood pressure trait   (VT:2000000)    
Bp15 Blood pressure QTL 15 blood pressure trait   (VT:0000183)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
RGSC_v3.4 SHRSP/Gcrc (MDC) View Damaging Variants
RGSC_v3.4 SHRSP/Gcrc (ICL) View Damaging Variants
Rnor_5.0 SHRSP/Gcrc (KNAW) View Damaging Variants
Rnor_6.0 SHRSP/Gcrc (RGD) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other larger (compared to WKY/Gcrc) apparent diffusion coefficient (ADC) lesion is observed within 1 hr of stroke 2313614
strain_other significant ischemic damage and a smaller penumbra is observed from 1-6 hrs after stroke 2313614