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Strain Registration

Strain: SD-Tg(TRE-TARDBP-M337V)

Symbol: SD-Tg(TRE-TARDBP-M337V)
Strain: SD-Tg(TRE-TARDBP-M337V)
RGD ID: 7245494
Citation ID: RRID:RRRC_00633
Ontology ID: RS:0003437
Alleles: TARDBP
Also Known As: TRE-TDP43-M337V; SD-Tg(TRE-TDP43-M337V)
Type: transgenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: Strain carries a transgene expressing human TDP43 with the M337V mutation under control of a tTA-dependent promoter (TRE). When mated to a second transgenic strain (RRRC:632) that carries a tetracycline-controlled transactivator driven by the mouse choline acetyltransferase (Chat) promoter, the expression of mutant TDP43 in Chat-expressing motor neurons in the double transgenic rats can be induced by withdrawal of doxycycline.
Coat Color: albino
Last Known Status: Cryopreserved Sperm (as of 2019-02-05)





Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. Reactive astrocytes secrete lcn2 to promote neuron death. Bi F, etal., Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4069-74. doi: 10.1073/pnas.1218497110. Epub 2013 Feb 19.
2. Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats. Huang C, etal., J Clin Invest. 2012 Jan 3;122(1):107-18. doi: 10.1172/JCI59130. Epub 2011 Dec 12.
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Transgenic rat model of neurodegeneration caused by mutation in the TDP gene. Zhou H, etal., PLoS Genet. 2010 Mar 26;6(3):e1000887. doi: 10.1371/journal.pgen.1000887.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-30 SD-Tg(TRE-TARDBP-M337V)    SD-Tg(TRE-TDP43-M337V)    Symbol and/or name change 68913 APPROVED
2013-06-06 SD-Tg(TRE-TDP43-M337V)    SD-Tg(TRE-TDP43-M337V)    Name updated 68913 APPROVED
2013-06-06 SD-Tg(TRE-TDP43-M337V)    SD-Tg(TRE-TDP43-M337V)    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00633 RGD