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Strain Registration

Strain: SS-Kcnj16em1Mcwi-/-

Symbol: SS-Kcnj16em1Mcwi-/-
Strain: SS-Kcnj16em1-/-
Substrain: Mcwi
RGD ID: 6893434
Citation ID: RRID:RGD_6893434
Ontology ID: RS:0003320
Alleles: Kcnj16em1Mcwi
Also Known As: SS-Kcnj16em1Mcwi; SS-Kcnj16em1Mcwi; SS-Kcnj16^[em1Mcwi-/-]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: This strain was produced by injecting ZFNs targeting the sequence AGCTGCATCATAAACACCttcatcATTGGGGCAGCCTTGGCA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 18-bp deletion in exon 1.
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21096,018,462 - 96,018,479RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01099,330,894 - 99,391,551RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01099,027,026 - 99,087,674RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.410100,514,180 - 100,515,949RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Essential role of Kir5.1 channels in renal salt handling and blood pressure control. Palygin O, etal., JCI Insight. 2017 Sep 21;2(18). pii: 92331. doi: 10.1172/jci.insight.92331. eCollection 2017 Sep 21.
3. PhysGen Knockouts PhysGen Knockout strains
4. Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis. Puissant MM, etal., FASEB J. 2019 Apr;33(4):5067-5075. doi: 10.1096/fj.201802257R. Epub 2019 Jan 3.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Kcnj16em1Mcwi-var1 chr10 96018462 96018479 CTTCATCATTGGGGCAGC - deletion mRatBN7.2

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-19 SS-Kcnj16em1Mcwi-/-    SS-Kcnj16em1Mcwi    Symbol and/or name change 68913 APPROVED
2014-04-03 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Name updated 68913 APPROVED
2014-04-03 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Name updated 68913 APPROVED
2013-08-15 SS-Kcnj16em1Mcwi    SS-Kcnj16em1Mcwi    Name updated 68913 APPROVED