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Strain Registration

Strain: PKD

Symbol: PKD
Strain: PKD
Full Name: PKD
RGD ID: 68118
Citation ID: RRID:RGD_68118
Ontology ID: RS:0000642
Type: inbred
Available Source: Not Available
Origination: Central Institute for Laboratory Animal Breeding, Hanover, Germany
Description: Outbred Han:SPRD-cy/+ Sprague-Dawley rats from the Zentralinstitut furVersuchstierkunde, Hannover, Germany to Dr. Bettina Kranzlin, Mannheim, Germany. Brother xsister inbreeding started in 1991.
Genetic Markers: cy/+
Coat Color: PKD
Inbred Generations: F16
Last Known Status: Unknown

Substrains
PKD/Mhm

Mutant Strains
PKD/Mhm




Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
PKD  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
kidney mass  EXP 629573 RGD 


References

References - curated
# Reference Title Reference Citation
1. Location of the first genetic locus, PKDr1, controlling autosomal dominant polycystic kidney disease in Han:SPRD cy/+ rat. Bihoreau MT, etal., Hum Mol Genet 1997 Apr;6(4):609-13.
2. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
3. Rat Strain List M. Festing Rat Strain List
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease. Schafer K, etal., Kidney Int 1994 Jul;46(1):134-52.

Region

Strain QTL Data
Symbol Name Trait
Kidm8 Kidney mass QTL 8 kidney mass   (VT:0002707)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Develops autosomal dominant polycystic kidney disease accompanied by increased kidney mass and urea concentration which is a model for human PKD 629573