Strain Report - Rat Genome Database

Strain Report - Rat Genome Database

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Strain Registration

General

Strain: M520
Symbol:	M520
Strain:	M520
RGD ID:	68086
Citation ID:	RRID:RGD_68086
Ontology ID:	RS:0000572
Type:	inbred
Available Source:	Not Available
Description:	Curtiss 1920, Columbia University Institute for Cancer Research, to Heston in 1949 at F49. To NIH in 1951 at F51 (Hansen et al 1982). A congenic strain lacking vasopressin due to the presence of the diabetes insipidus gene, di (from the Brattleboro rat) has been described (Colombo et al, 1992).
Genetic Markers:	a,c,h.
Coat Color:	Albino.
Inbred Generations:	F148
Last Known Status:	Unknown

Substrains

Annotation Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	Inbred Strains	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2.	Rat Strain List	M. Festing Rat Strain List
3.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_life_disease	Intermediate survival to 2 years of age at 59% in males and 62% in females. There was a relatively high incidence of mild chronic renal disease and a high incidence of hydronephrosis which may make the strain unsuitable for long-term toxicity studies (though diet may have an important influence) (Solleveld and Boorman 1986). Susceptible to Cysticercus. NIH subline has a 21-25% incidence of adrenal medulla tumours. Susceptible to induction of tumours by 2-acetylaminofluorine (Symeonidis 1954). Low frequency of pancreatic exocrine tumours. By 12-15 months of age develop small local areas of nephritis that progress by 22-24 months to moderate to severe nephritis in 75% of animals (Snell 1967). About 33% of females over 18 months develop tumours of the uterus of endometrial origin. Adrenocortical adenomas (about 20% in males and 40% in females over 18 months of age), and phaeochromocytomas or preneoplastic nodules in adrenal medulla (about 67% of males over 21 months of age) (Snell 1965). Low blood pressure (21/23), reaching 121_1.2 (SEM) mmHg at 10 weeks of age. Resistant to development of methlycholanthrene -induced thyroiditis (Glover et al 1969).	1004
strain_life_disease	Intermediate survival to 2 years of age at 59% in males and 62% in females. There was a relatively high incidence of mild chronic renal disease and a high incidence of hydronephrosis which may make the strain unsuitable for long-term toxicity studies (though diet may have an important influence) (Solleveld and Boorman 1986). Susceptible to Cysticercus. NIH subline has a 21-25% incidence of adrenal medulla tumours. Susceptible to induction of tumours by 2-acetylaminofluorine (Symeonidis 1954). Low frequency of pancreatic exocrine tumours. By 12-15 months of age develop small local areas of nephritis that progress by 22-24 months to moderate to severe nephritis in 75% of animals (Snell 1967). About 33% of females over 18 months develop tumours of the uterus of endometrial origin. Adrenocortical adenomas (about 20% in males and 40% in females over 18 months of age), and phaeochromocytomas or preneoplastic nodules in adrenal medulla (about 67% of males over 21 months of age) (Snell 1965). Low blood pressure (21/23), reaching 121_1.2 (SEM) mmHg at 10 weeks of age. Resistant to development of methlycholanthrene -induced thyroiditis (Glover et al 1969).	634612
strain_phys_biochem	Low systolic blood pressure (16/17) (Hansen et al 1973). Low hepatic metabolism of anilene (9/10 in males, 7/10 in females), but high metabolism of ethylmorphine (1/10) (Page and Vesell 1969). Low 10-week body weight in males (5/23) (Tanase et al 1982). High relative heart weight in 10-week old males (21/23) (Tanase et al 1982). Lacks the phenobarbital-inducible cytochrome P450 2B2 (Cyp2B2) in hepatic microsomes due to a mutation in a single autosomal gene, with codominant inheritance with respect to protein and mRNA phenotypes (see also MW) (Omiecinski et al, 1992).	1004
strain_phys_biochem	Low systolic blood pressure (16/17) (Hansen et al 1973). Low hepatic metabolism of anilene (9/10 in males, 7/10 in females), but high metabolism of ethylmorphine (1/10) (Page and Vesell 1969). Low 10-week body weight in males (5/23) (Tanase et al 1982). High relative heart weight in 10-week old males (21/23) (Tanase et al 1982). Lacks the phenobarbital-inducible cytochrome P450 2B2 (Cyp2B2) in hepatic microsomes due to a mutation in a single autosomal gene, with codominant inheritance with respect to protein and mRNA phenotypes (see also MW) (Omiecinski et al, 1992).	634612
strain_reproduction	Good breeding performance (2/12) and intermediate litter size (6/12) (Hansen et al 1973).	1004
strain_reproduction	Good breeding performance (2/12) and intermediate litter size (6/12) (Hansen et al 1973).	634612