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Strain Registration

Strain: LETL

Symbol: LETL
Strain: LETL
RGD ID: 68073
Citation ID: RRID:RGD_68073
Ontology ID: RS:0001348
Type: inbred
Available Source: Not Available
Description: A rat with spontaneous polyurea, polyphagia and polydipsia was found in a colony of outbred Long Evans rats purchased from Charles River in 1982. Selective breeding for diabetes with brother x sister mating was subsequently started at the Tokushima Research Institute, Otsuka Pharmaceutical Co., Japan
Genetic Markers: a,h.
Coat Color: Black hooded.
Inbred Generations: F20 (1989)
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. New inbred strain of Long-Evans Tokushima lean rats with IDDM without lymphopenia. Kawano K, etal., Diabetes 1991 Nov;40(11):1375-81.
3. Rat Strain List M. Festing Rat Strain List
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat. Yokoi N, etal., J Clin Invest 1997 Oct 15;100(8):2015-21.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics About 30% of rats develop insulin-dependent diabetes mellitus. Onset is abrupt at 8 to 20 weeks,of equal severity in both sexes, and the animals are not obese. Clinical symptoms includehyperglycemia, glycosurea, ketonia, polyurea polydipsia and polyphagia. There is destruction ofthe pancreatic / cells and lymphocytic infiltration of the submaxillary and lacrimal glands. There isno significant T lymphopenia, but there is lymphocytic infliltration into the salivary and lacrimalglands. Genetic analysis suggests that the condition involves at least two genes, one of which islinked to RT1u. A non-diabetic control strain LETO, has been developed from the same basepopulation. The strain has been characterised at 21 marker loci (Kawano et al 1989, Kawano etal, 1991) 1004
strain_characteristics About 30% of rats develop insulin-dependent diabetes mellitus. Onset is abrupt at 8 to 20 weeks,of equal severity in both sexes, and the animals are not obese. Clinical symptoms includehyperglycemia, glycosurea, ketonia, polyurea polydipsia and polyphagia. There is destruction ofthe pancreatic / cells and lymphocytic infiltration of the submaxillary and lacrimal glands. There isno significant T lymphopenia, but there is lymphocytic infliltration into the salivary and lacrimalglands. Genetic analysis suggests that the condition involves at least two genes, one of which islinked to RT1u. A non-diabetic control strain LETO, has been developed from the same basepopulation. The strain has been characterised at 21 marker loci (Kawano et al 1989, Kawano etal, 1991) 634612
strain_life_disease These rats have an onset of overt diabetes and no difference is noticed in between the sexes. 634732