Strain Report - Rat Genome Database

Strain Report - Rat Genome Database

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Strain Registration

General

Strain: LA/N
Symbol:	LA/N
Strain:	LA
Substrain:	N
RGD ID:	68062
Citation ID:	RRID:RGD_68062
Ontology ID:	RS:0000420
Also Known As:	LA
Type:	inbred
Available Source:	Not Available
Origination:	NIH Autoimmune Rat Model Repository and Development Center
Description:	from a cross between ALB/N and a hooded stock of unknown origin (Hansen et al 1982).
Genetic Markers:	a,H.
Coat Color:	Black
Inbred Generations:	F89 (NIH 1989)
Last Known Status:	Extinct

Annotation Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	Inbred Strains	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2.	Rat Strain List	M. Festing Rat Strain List
3.	NIH Rat Strain Data	NIH Rat Strain Data
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	Good reproductive performance. LA is mainly used as control for congenic strain LA/N-cp (ie carrying the corpulent gene, an allele of fatty) in studies of obesity (see Tulp 1990 for a review).High 10-week body weight in males (21/23) (Tanase et al 1982). Low relative heart weight in10-week old males (1/23) (Tanase et al 1982). Diabetes in LA/N-cp occurs in 80% of maleobese and 17% of female obese rats from six months of age (Tulp and Weng, 1992). Glucose turnover in lean and obese LA rats has been described by Berdanier et al, (1993). Obese rats have twice the capacity to synthesise body fat and cholesterol, but have a reduced capacity to degrade cholesterol, leading to an accumulation of cholesterol and fat (Ghosh et al, 1995).	1004
strain_characteristics	Good reproductive performance. LA is mainly used as control for congenic strain LA/N-cp (ie carrying the corpulent gene, an allele of fatty) in studies of obesity (see Tulp 1990 for a review).High 10-week body weight in males (21/23) (Tanase et al 1982). Low relative heart weight in10-week old males (1/23) (Tanase et al 1982). Diabetes in LA/N-cp occurs in 80% of maleobese and 17% of female obese rats from six months of age (Tulp and Weng, 1992). Glucose turnover in lean and obese LA rats has been described by Berdanier et al, (1993). Obese rats have twice the capacity to synthesise body fat and cholesterol, but have a reduced capacity to degrade cholesterol, leading to an accumulation of cholesterol and fat (Ghosh et al, 1995).	634612

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-04-07	LA/N		LA/N		Name updated	68913	APPROVED
2015-04-07	LA/N		LA/N		Name updated	68913	APPROVED
2015-04-07	LA/N		LA/N		Name updated	68913	APPROVED
2015-04-07	LA/N		LA/N		Name updated	68913	APPROVED
2013-04-15	LA/N		LA/N		Name updated	68913	APPROVED
2013-04-15	LA/N		LA/N		Name updated	68913	APPROVED
2003-11-12	LA/N		LA		Symbol Updated	728213	APPROVED