Strain Report - Rat Genome Database

Strain Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Strain Registration

General

Strain: BDV
Symbol:	BDV
Strain:	BDV
RGD ID:	67981
Citation ID:	RRID:RGD_67981
Ontology ID:	RS:0000094
Type:	inbred
Available Source:	Not Available
Description:	Druckrey 1937 from a yellow, pink-eyed strain. Inbred and reduced to one pair after World War II. Crosses with Wistar stock and subsequent inbreeding led to the development of BDII. According to Druckrey (1971), strains BDIII-BDX were then developed from a cross of a single BDI x BDII mating pair, with subsequent selection for coat colour alleles. However, the strains have four different RT1 haplotypes (d, v, l and e) rather than the two that would be expected from such a cross (Stark and Zeiss 1970). The strains can _not_ be regarded as a set of recombinant inbred strains as defined by Bailey (1971), although their definition by coat colour alleles makes the set easily identifiable , and should help (but not guarantee!) to ensure authenticity. According to Druckrey (1971), all strains have a low tumour incidence, with a median life-span of 700-950 days, depending on strain.
Genetic Markers:	a,C,h,p.
Coat Color:	Pink-eyed, non-agouti, hooded.
Inbred Generations:	F ?+50
Last Known Status:	Unknown

Substrains

Annotation Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	[Transplacental induction of malignant tumours of the nervous system. II. Ethyl-nitrosurea in 10 genetically defined strains of rats]	Druckrey H, etal., Z Krebsforsch 1970 Mar 10;73(4):371-86.
2.	Inbred Strains	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
3.	Rat Strain List	M. Festing Rat Strain List
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	Strain widely used in carcinogenesis and teratogenesis studies. Highly susceptible to the transplacental induction of malignant tumours of the central nervous system by ethyl nitrosourea (Druckrey et al 1970). A transplantable monocytic-myeloid leukaemia L5222 induced by ethyl nitrosourea has been used as a model for chemotherapy (Ivankovic and Zeller 1974). Transplantable colon tumour PROb grows progressively and metastasizes, whereas REGb grows slowly and is then rejected (Blottiere et al 1992a,b). DHD/K12 colon adenocarcinoma cells also metastasize, but RC-160 acts as an inhibitor (Qin et al 1992). These models have been used to study methods of treating peritoneal carcinoma including shockwave cavitation (Prat et al 1993) and the somatostatiin analog Lanreotide and the GRP antagonist BIM-26226 (Gouyon et al 1995). A transplantable ovarian carcinoma O-342 has been used in studies of potential chemotherapeutic use of a methotrexate-albumin conjugate (Steinmann et al 1995). Transplantable Sp-5 colorectal adenocarcinoma has been used in the study of the chemotherapeutic effects of 2-deoxy-5-fluorouridine for pulmonary metastises (Ng et al 1995). Has a defect in the expression of RT1.B, apparently due to absence of structural or controling gene (Male et al 1987). The activity of C-jun, JunB, JunD, Krox-24 and C-fos in the brain shows individual patterns of expression in untreated animals (Herdegen et al 1995).	1004
strain_characteristics	Strain widely used in carcinogenesis and teratogenesis studies. Highly susceptible to the transplacental induction of malignant tumours of the central nervous system by ethyl nitrosourea (Druckrey et al 1970). A transplantable monocytic-myeloid leukaemia L5222 induced by ethyl nitrosourea has been used as a model for chemotherapy (Ivankovic and Zeller 1974). Transplantable colon tumour PROb grows progressively and metastasizes, whereas REGb grows slowly and is then rejected (Blottiere et al 1992a,b). DHD/K12 colon adenocarcinoma cells also metastasize, but RC-160 acts as an inhibitor (Qin et al 1992). These models have been used to study methods of treating peritoneal carcinoma including shockwave cavitation (Prat et al 1993) and the somatostatiin analog Lanreotide and the GRP antagonist BIM-26226 (Gouyon et al 1995). A transplantable ovarian carcinoma O-342 has been used in studies of potential chemotherapeutic use of a methotrexate-albumin conjugate (Steinmann et al 1995). Transplantable Sp-5 colorectal adenocarcinoma has been used in the study of the chemotherapeutic effects of 2-deoxy-5-fluorouridine for pulmonary metastises (Ng et al 1995). Has a defect in the expression of RT1.B, apparently due to absence of structural or controling gene (Male et al 1987). The activity of C-jun, JunB, JunD, Krox-24 and C-fos in the brain shows individual patterns of expression in untreated animals (Herdegen et al 1995).	634612