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Strain Registration

Strain: E3/ZtmRhd

Symbol: E3/ZtmRhd
Strain: E3
Substrain: ZtmRhd
RGD ID: 634374
Citation ID: RRID:RGD_634374
Ontology ID: RS:0000208
Also Known As: MDC-01-85; E3/HanRhd
Type: inbred
Available Source: Not Available
Origination: Section for Medical Inflammation Research, Biomedical Center, Lund University, Sweden
Description: E3 rats originating from Zentralinstitut fur Versuchstierzucht, Hannover, Germany and kept at Lund University.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Complex genetic control in a rat model for rheumatoid arthritis. Nordquist N, etal., J Autoimmun 2000 Dec;15(4):425-32.
2. Identification and isolation of dominant susceptibility loci for pristane-induced arthritis. Olofsson P, etal., J Immunol 2003 Jul 1;171(1):407-16.
3. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Olofsson P, etal., Nat Genet 2003 Jan;33(1):25-32.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Detection of arthritis-susceptibility loci, including Ncf1, and variable effects of the major histocompatibility complex region depending on genetic background in rats. Rintisch C, etal., Arthritis Rheum. 2009 Feb;60(2):419-27.
6. Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in rats. Rintisch C, etal., Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14005-10. Epub 2008 Sep 8.
7. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
8. The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis. Wernhoff P, etal., Arthritis Rheum. 2003 Dec;48(12):3584-96.

Region

Strain QTL Data
Symbol Name Trait
Pia15 Pristane induced arthritis QTL 15 joint integrity trait   (VT:0010548)    
Pia16 Pristane induced arthritis QTL 16 joint integrity trait   (VT:0010548)    
Pia17 Pristane induced arthritis QTL 17 joint integrity trait   (VT:0010548)    
Pia18 Pristane induced arthritis QTL 18 joint integrity trait   (VT:0010548)    
Pia19 Pristane induced arthritis QTL 19 joint integrity trait   (VT:0010548)    
Pia27 Pristane induced arthritis QTL 27 blood immunoglobulin amount   (VT:0002460)    
Pia28 Pristane induced arthritis QTL 28 blood autoantibody amount   (VT:0003725)    
Pia29 Pristane induced arthritis QTL 29 blood autoantibody amount   (VT:0003725)    
Pia30 Pristane induced arthritis QTL 30 blood autoantibody amount   (VT:0003725)    
Pia31 Pristane induced arthritis QTL 31 blood autoantibody amount   (VT:0003725)    
Pia32 Pristane induced arthritis QTL 32 blood autoantibody amount   (VT:0003725)    
Pia33 Pristane induced arthritis QTL 33 blood immunoglobulin amount   (VT:0002460)    
Pia34 Pristane induced arthritis QTL 34 blood immunoglobulin amount   (VT:0002460)    
Pia35 Pristane induced arthritis QTL 35 blood immunoglobulin amount   (VT:0002460)    
Pia36 Pristane induced arthritis QTL 36 blood immunoglobulin amount   (VT:0002460)    
Pia37 Pristane induced arthritis QTL 37 blood immunoglobulin amount   (VT:0002460)    
Pia38 Pristane induced arthritis QTL 38 blood immunoglobulin amount   (VT:0002460)    
Pia39 Pristane induced arthritis QTL 39 blood immunoglobulin amount   (VT:0002460)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease These rats are resistant to pristane-induced arthritis. 631850
strain_phys_biochem These have an elevated level of rheumatoid factors as compared to DA/ZtmRhd 2302066