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General

Strain: FHH-Chr 1^BN/Mcwi
Symbol:	FHH-Chr 1^BN/Mcwi
Strain:	FHH-Chr 1^BN
Substrain:	Mcwi
Ontology ID:	RS:0000329
Also known as:	FHH-1BN/Mcwi; FHH-1^BN/EurMcw_i; FHH-1BN/Mcwi;FHH-1^BN/Mcwi;FHH-Chr 1BN/Mcwi
Type:	consomic
Source:	PhysGen
Origin:	A cross of FHH and BN strains which results in a FHH genomic background with a BN chromosome introgressed
Genetic Markers:	hooded
Coat Color:	brown

Annotation (Toggle Detail/Summary View)

Phenotype Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
decreased urine protein level		IED		1579884		RGD

Phenotype Values via Phenominer

Related Phenotype Data for Term "FHH-Chr 1BN/Mcwi" (RS:0000329)

Rat Strains:

FHH-Chr 1BN/Mcwi

Clinical Measurements:

absolute change in blood pH
absolute change in body temperature
absolute change in heart rate
absolute change in mean arterial blood pressure
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
acetylcholine half maximal effective concentration (EC50)
acetylcholine Log half maximal effective concentration (Log EC50)
acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
arterial blood flow rate
blood hemoglobin level
blood pH
body temperature
body weight
calculated pulmonary vascular resistance normalized to body weight
creatinine clearance
eosinophil granulocyte count
FAPGG metabolism-surface area product
fractional change in blood vessel diameter per unit change in intravascular pressure
heart contraction pressure
heart effluent lactate dehydrogenase activity level normalized to heart weight
heart left ventricle infarction weight as percentage of total heart left ventricle weight
heart rate
heart right ventricle weight to left ventricle weight ratio
heart weight as percentage of body weight
heart wet weight
hematocrit (Hct)
hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction
left ventricle developed pressure
left ventricle diastolic blood pressure
left ventricle systolic blood pressure
lung weight, dry/body weight ratio
lymphocyte count
maximum contractile force per wet weight of aorta
mean arterial blood pressure
mean corpuscular hemoglobin concentration (MCHC)
mean corpuscular hemoglobin level (MCH)
mean corpuscular volume (MCV)
methacholine median effective dose (ED50)
methylene blue metabolism-surface area product after auto-oxidation
methylene blue metabolism-surface area product without auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
minute ventilation (VE)
monocyte count
neutrophil granulocyte count
partial pressure of blood carbon dioxide (Pco2)
partial pressure of blood oxygen (Po2)
percent change in arterial blood flow rate
percent change in heart rate
percent change in left ventricle developed pressure
percent change in left ventricle systolic blood pressure
percent change in respiration rate
percent change in tidal volume
percent change in ventilation
phenylephrine half maximal effective concentration (EC50)
phenylephrine Log half maximal effective concentration (Log EC50)
plasma anion gap
plasma creatinine level
plasma renin activity level
ratio of change in renal blood flow to change in renal perfusion pressure
red blood cell count
respiration rate
serum alanine amino transferase (ALT) level
serum albumin level
serum alkaline phosphatase level
serum aspartate amino transferase (AST) level
serum bicarbonate level
serum calcium level
serum chloride level
serum globulin level
serum glucose level
serum phosphate level
serum potassium level
serum sodium level
serum total cholesterol level
serum total protein level
serum urea nitrogen level
sodium nitroprusside half maximal effective concentration (EC50)
sodium nitroprusside Log half maximal effective concentration (Log EC50)
sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction
tidal volume
time to onset of heart contraction
time to peak heart contraction
total serum bilirubin level
total white blood cell count
urine albumin excretion rate
urine potassium excretion rate
urine sodium excretion rate
urine total protein excretion rate

Experimental Conditions:

acetylcholine
air carbon dioxide content
air oxygen content
controlled in situ renal perfusion pressure
controlled NG-nitroarginine methyl ester content drinking water
controlled oxygen content Kreb's solution perfusate
controlled oxygen content physiological salt solution perfusate
controlled sodium content diet
drug dose time series
FAPGG
Kreb's solution perfusate
methacholine
methylene blue
naive control condition
perfusate suspended
phenylephrine
potassium ion
resting on treadmill
running on treadmill
sample resting period
sodium nitroprusside
walking on treadmill

Measurement Methods:

automated blood cell counter
automated plasma creatinine analysis
automated urine total protein analysis
balloon tipped catheter with pressure transducer in isolated perfused heart
Bayer automated gas analyzer
digital rectal thermometer
digital scale post excision weight measurement
flame atomic emission spectrometry
fluid-filled catheter with pressure transducer in isolated perfused lung
isolated perfused heart effluent collection
isolated perfused lung vascular effluent collection
microhematocrit tube assay with visual assessment
radioimmunoassay
standard blood chemistry panel
stop flow air displacement plethysmography
ultrasonic flowmeter
urine creatinine analysis
vascular fluid filled catheter
whole body digital scale
wire myography using a Digi-Med tissue force analysis system with force transducer

Phenotype Annotations

decreased urine protein level (IED)

Phenotype Values via Phenominer

Options:

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View expanded data table

Clinical Measurement

heart rate

left ventricle diastolic blood pressure

left ventricle systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricle developed pressure

red blood cell count

blood hemoglobin level

neutrophil granulocyte count

lymphocyte count

monocyte count

eosinophil granulocyte count

hematocrit (Hct)

mean corpuscular volume (MCV)

plasma anion gap

heart wet weight

heart weight as percentage of body weight

lung weight, dry/body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation (VE)

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin level (MCH)

mean corpuscular hemoglobin concentration (MCHC)

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

serum total cholesterol level

total white blood cell count

total serum bilirubin level

blood pH

partial pressure of blood oxygen (Po2)

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine amino transferase (ALT) level

serum alkaline phosphatase level

serum aspartate amino transferase (AST) level

serum urea nitrogen level

serum globulin level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight as percentage of total heart left ventricle weight

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

methacholine median effective dose (ED50)

fractional change in blood vessel diameter per unit change in intravascular pressure

phenylephrine half maximal effective concentration (EC50)

phenylephrine Log half maximal effective concentration (Log EC50)

acetylcholine half maximal effective concentration (EC50)

acetylcholine Log half maximal effective concentration (Log EC50)

sodium nitroprusside half maximal effective concentration (EC50)

sodium nitroprusside Log half maximal effective concentration (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction

sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction

hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricle developed pressure

percent change in left ventricle systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine potassium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

ratio of change in renal blood flow to change in renal perfusion pressure

References - curated

1.	Lopez B, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22.
2.	Mattson DL, etal., Am J Physiol Renal Physiol 2005 May;288(5):F1015-22. Epub 2005 Jan 11.
3.	PhysGen strains

RGD Disease Portals

FHH-Chr 1^BN/Mcwi has been annotated in the following RGD Disease Portals.

Diabetes Phenotypes

Region

Strain QTL Data

Symbol	Name	Trait	Subtrait
Rf55	Renal function QTL 55	Renal function	renal blood flow

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_life_disease	The blood pressure of females is 113 mmHg and of males is 126 mmHg.	629526
strain_life_disease	This consomic strain demonstrates reduced hypertension and renal disease as compared to the paretal FHH/EurMcwi strain	1547854
strain_other	The average weight of females is 170g and of males 224g.	629526
strain_reproduction	The average litter size is 9.6 pups and the average generation time is 41 days.	629526

More on this Strain
	Strain Nomenclature
	Strain Registration

RGD Object Information
RGD ID:	629520
Created:	2003-05-16
Species:	Rattus norvegicus
Last Modified:	2009-06-15
Status:	ACTIVE

Strain: FHH-Chr 1BN/Mcwi

Related Phenotype Data for Term "FHH-Chr 1BN/Mcwi" (RS:0000329)

Strain: FHH-Chr 1^BN/Mcwi