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Strain Registration

Strain: Ni/Hin

Symbol: Ni/Hin
Strain: Ni
Substrain: Hin
RGD ID: 628525
Citation ID: RRID:RGD_628525
Ontology ID: RS:0000614
Also Known As: Nihon Rat
Type: inbred
Available Source: Not Available
Origination: Clea Japan Inc. Shiga
Description: Found in the Sprague-Dawley (Jci:SD) in Japan. In these the Tsc2 gene is not mutated. In this rat strain mutation was identified as an insertion of a cytosine (C) in a C tract within exon 3 of Flcn . This germline mutation results in a frameshift and produces a stop codon 26 amino-acids downstream
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma. Okimoto K, etal., Jpn J Cancer Res 2000 Nov;91(11):1096-9.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy They have multiple cysts on the kidney. 628433
strain_life_disease This is a good model for clear cell type renal cell carcinoma (RC). RC can be observed at 4 weeks which develops into adenoma at 16 weeks. These have large carcinoma with frequent hemorrhages and necrosis. 628433
strain_phys_biochem About 4% ofthe rats had bilateral multicentric renal tubule tumors. Most of the atypical tumors were clear cell or mixed cell (clear/ acidophilic cell) type. 628433