Department of Experimental Pathology, Cancer Institute, Toshima-ku, Tokyo Japan
Description:
Eker rat is derived from the Long-Evans strain that has a mutation in Tsc2 gene. Originally reported by R. Eker in 1954 at the Norwegian Radium Hospital, Oslo.
Excellent example of a mendelian dominant predisposition to a specific cancer in an experimental animal. The Eker mutation is tightly linked to the Tsc2 gene. Renal carcinoma is developed in multiple stages from early preneoplastic lesions. This model is highly susceptible to particular cancers, develops multiple renal tumors. The Eker rat has a single gene mutation in the Tsc2 gene that develops into four different tumors in the kidney, spleen, uterus and pitutary.
Eker rats develop multicentric, bilateral tumors that are scattered throughout the renal cortex and the medulla. Male rats have approximately double the number of tumors as the female at 10 months of age.
After unilateral nephrectomy these were diagnosed as carriers for the histologic detection of tumors in the kidney of at 4-10 months of age. Most tumors have periodic acid/ Schiff-negative large cells with clear, finely granular or vacuolated cytoplasm. Some tumors are cystic or have papillary projections. Derived cell lines represent tumor cell derivatives.