| Note Type |
Note |
Reference |
| strain_life_disease |
Developes focal and segmental glomerular sclerosis, systemic hypertension and proteinuria at ayoung age, but these effects are more marked in FHH than FHL (Simons et al, 1993). The renal disease and hypertension are under independent genetic control, and both appear to be independent of the red-eyed dilution gene which causes platelet storage disease (Brown et al,1996). Glomerular filtration rate (GFR), renal blood flow (RBF), and glomerular capillary pressure (PGC) are elevated in FHH rats suggest that the control of renal vascular resistance may be altered in this strain. |
1004
|
| strain_life_disease |
Developes focal and segmental glomerular sclerosis, systemic hypertension and proteinuria at ayoung age, but these effects are more marked in FHH than FHL (Simons et al, 1993). The renal disease and hypertension are under independent genetic control, and both appear to be independent of the red-eyed dilution gene which causes platelet storage disease (Brown et al,1996). Glomerular filtration rate (GFR), renal blood flow (RBF), and glomerular capillary pressure (PGC) are elevated in FHH rats suggest that the control of renal vascular resistance may be altered in this strain. |
61090
|
| strain_life_disease |
Developes focal and segmental glomerular sclerosis, systemic hypertension and proteinuria at ayoung age, but these effects are more marked in FHH than FHL (Simons et al, 1993). The renal disease and hypertension are under independent genetic control, and both appear to be independent of the red-eyed dilution gene which causes platelet storage disease (Brown et al,1996). Glomerular filtration rate (GFR), renal blood flow (RBF), and glomerular capillary pressure (PGC) are elevated in FHH rats suggest that the control of renal vascular resistance may be altered in this strain. |
634612
|
| strain_life_disease |
A good model for platelet storage pool deficiency with low blood serotinin level than the BN rats. The blood coagulation time and platelet count is normal. |
1300411
|
| strain_other |
Have Rab38 Met1Ile mutation which is responsible for fawn-hooded pigmentary dilution and platelet storage pool deficiency |
1300411
|
| strain_phys_biochem |
Autoregulation of renal blood flow (RBF) is impaired in FHH rats before the development of glomerulosclerosis and suggest that an abnormality in the control of renal vascular resistance may contribute to the development of proteinuria and renal failure in this strain of rats. RBF and Glomerular filtration rate (GFR) are markedly elevated in FHH rats compared with values observed in fawn-hooded low blood pressure (FHL) rats. Urinary protein excretion was directly dependent on the changes in renal perfusion pressure (RPP) in FHH rats. The mechanism involved in this unusual pressure proteinuric response may be dependent on the GFR and the impaired autoregulation of RBF and GFR in response to elevations in RPP. |
1004
|
| strain_phys_biochem |
Autoregulation of renal blood flow (RBF) is impaired in FHH rats before the development of glomerulosclerosis and suggest that an abnormality in the control of renal vascular resistance may contribute to the development of proteinuria and renal failure in this strain of rats. RBF and Glomerular filtration rate (GFR) are markedly elevated in FHH rats compared with values observed in fawn-hooded low blood pressure (FHL) rats. Urinary protein excretion was directly dependent on the changes in renal perfusion pressure (RPP) in FHH rats. The mechanism involved in this unusual pressure proteinuric response may be dependent on the GFR and the impaired autoregulation of RBF and GFR in response to elevations in RPP. |
61090
|
| strain_phys_biochem |
Autoregulation of renal blood flow (RBF) is impaired in FHH rats before the development of glomerulosclerosis and suggest that an abnormality in the control of renal vascular resistance may contribute to the development of proteinuria and renal failure in this strain of rats. RBF and Glomerular filtration rate (GFR) are markedly elevated in FHH rats compared with values observed in fawn-hooded low blood pressure (FHL) rats. Urinary protein excretion was directly dependent on the changes in renal perfusion pressure (RPP) in FHH rats. The mechanism involved in this unusual pressure proteinuric response may be dependent on the GFR and the impaired autoregulation of RBF and GFR in response to elevations in RPP. |
634612
|
Substrains
