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Strain: GK/MolTac

Symbol: GK/MolTac
Strain: GK
Substrain: MolTac
Full Name: Goto-Kakizaki
RGD ID: 1566447
Citation ID: RRID:RGD_1566447
Ontology ID: RS:0001317
Type: inbred
Available Source: Taconic
Origination:
Description: The Goto-Kakizaki inbred model was developed by Tohoku University in 1975. Aarhus University Hospital in Denmark received stock in 1994. M&B A/S (now Taconic Europe) received stock from Aarhus in 1997. The rats were derived by embryo transfer in 2005 at Taconic US.
Coat Color: Albino
Last Known Status: Unknown





Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "GK/MolTac" (RS:0001317)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
left ventricular diastolic blood pressure
mean arterial blood pressure
body weight
heart weight
red blood cell count
blood hemoglobin level
hematocrit
plasma glucose level
blood glucose level
heart wet weight
right kidney wet weight
left kidney wet weight
both kidneys wet weight
liver weight
plasma renin activity level
liver wet weight
ejection fraction
cardiac output
systemic vascular resistance
stroke volume
both kidneys wet weight to body weight ratio
plasma insulin level
blood insulin level
serum insulin level
urine glucose level
food intake rate
serum aldosterone level
heart left ventricle weight to body weight ratio
plasma triglyceride level
plasma total cholesterol level
plasma troponin T level
urine norepinephrine level
maximum rate of positive change in left ventricular blood pressure
maximum rate of negative change in left ventricular blood pressure
time constant of left ventricular pressure decay
blood malondialdehyde level
blood hemoglobin A1c level
serum fructosamine level
plasma NH2-terminal pro-B-type natriuretic peptide level
cardiac index
stroke index
arterial elastance
preload recruitable left ventricle stroke work
maximum rate of positive change in left ventricular blood pressure to left ventricular end-diastolic volume ratio
heart left ventricle end-diastolic posterior wall index
heart left ventricle end-diastolic anterior wall index
blood insulin level AUC to blood glucose level AUC ratio
whole body insulin sensitivity index
Homeostatic Model Assessment of Insulin Resistance
blood dipeptidyl peptidase 4 activity level
heart left ventricle end-diastolic diameter to body weight ratio
kidney glomerulus basement membrane thickness
kidney fractional mesangial volume
serum 8-epi-prostaglandin F2alpha level
serum amylase activity level
middle cerebral artery outer diameter
A23187-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
tissue mitochondrial DNA to nuclear DNA ratio

References

References - curated
# Reference Title Reference Citation
1. Personal Communication with Taconic Personal Communication with Taconic
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Fasting hyperglycemia and impaired secretion of insulin in response to glucose. 1559308
strain_other A non-obese model of Non-Insulin Dependent Diabetes Mellitus (NIDDM), type II diabetes. 1559308
strain_reproduction Average reproductive performance. 1559308