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General

Strain: SS-Chr 19^BN/Mcwi
Symbol:	SS-Chr 19^BN/Mcwi
Strain:	SS-Chr 19^BN
Substrain:	Mcwi
Ontology ID:	RS:0000800
Also known as:	SS-19^BN/Mcwi;SS-Chr 19BN/Mcwi;SS-19BN/Mcwi
Type:	consomic
Source:	PhysGen
Origin:	A SS genomic background with a BN chromosome 19 introgressed.
Coat Color:	Albino

Annotation (Toggle Detail/Summary View)

Phenotype Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
decreased incidence of chemically-induced tumors	Induced	IED		4143380	as compared to SS/JrHsdMcwi under DMBA induction	RGD

Phenotype Values via Phenominer

Related Phenotype Data for Term "SS-Chr 19BN/Mcwi" (RS:0000800)

Rat Strains:

SS-Chr 19BN/Mcwi

Clinical Measurements:

absolute change in blood pH
absolute change in body temperature
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
acetylcholine half maximal effective concentration (EC50)
acetylcholine Log half maximal effective concentration (Log EC50)
acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
arterial blood flow rate
blood hemoglobin level
blood pH
body temperature
body weight
calculated pulmonary vascular resistance normalized to body weight
creatinine clearance
eosinophil granulocyte count
FAPGG metabolism-surface area product
fractional change in blood vessel diameter per unit change in intravascular pressure
heart contraction pressure
heart effluent lactate dehydrogenase activity level normalized to heart weight
heart left ventricle infarction weight as percentage of total heart left ventricle weight
heart rate
heart right ventricle weight to left ventricle weight ratio
heart weight as percentage of body weight
heart wet weight
hematocrit (Hct)
left ventricle developed pressure
left ventricle diastolic blood pressure
left ventricle systolic blood pressure
lung weight, dry/body weight ratio
lymphocyte count
mammary tumor number
maximum contractile force per wet weight of aorta
mean arterial blood pressure
mean corpuscular hemoglobin concentration (MCHC)
mean corpuscular hemoglobin level (MCH)
mean corpuscular volume (MCV)
methacholine median effective dose (ED50)
methylene blue metabolism-surface area product after auto-oxidation
methylene blue metabolism-surface area product without auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
minute ventilation (VE)
monocyte count
neutrophil granulocyte count
partial pressure of blood carbon dioxide (Pco2)
partial pressure of blood oxygen (Po2)
percent change in arterial blood flow rate
percent change in heart rate
percent change in left ventricle developed pressure
percent change in left ventricle systolic blood pressure
percent change in respiration rate
percent change in tidal volume
percent change in ventilation
phenylephrine half maximal effective concentration (EC50)
phenylephrine Log half maximal effective concentration (Log EC50)
plasma anion gap
plasma creatinine level
plasma renin activity level
red blood cell count
respiration rate
serum alanine amino transferase (ALT) level
serum albumin level
serum alkaline phosphatase level
serum aspartate amino transferase (AST) level
serum bicarbonate level
serum calcium level
serum chloride level
serum globulin level
serum glucose level
serum phosphate level
serum potassium level
serum sodium level
serum total cholesterol level
serum total protein level
serum urea nitrogen level
tidal volume
time to mammary tumor formation, post insult
time to onset of heart contraction
time to peak heart contraction
total serum bilirubin level
total white blood cell count
urine albumin excretion rate
urine potassium excretion rate
urine sodium excretion rate
urine total protein excretion rate

Experimental Conditions:

7,12-dimethyltetraphene (DMBA)
acetylcholine
air carbon dioxide content
air oxygen content
controlled oxygen content Kreb's solution perfusate
controlled sodium content diet
drug dose time series
FAPGG
Kreb's solution perfusate
methacholine
methylene blue
naive control condition
perfusate suspended
phenylephrine
potassium ion
sample resting period

Measurement Methods:

automated blood cell counter
automated plasma creatinine analysis
automated urine total protein analysis
balloon tipped catheter with pressure transducer in isolated perfused heart
Bayer automated gas analyzer
digital rectal thermometer
digital scale post excision weight measurement
flame atomic emission spectrometry
fluid-filled catheter with pressure transducer in isolated perfused lung
isolated perfused heart effluent collection
isolated perfused lung vascular effluent collection
manual palpation method
microhematocrit tube assay with visual assessment
necropsy
radioimmunoassay
standard blood chemistry panel
stop flow air displacement plethysmography
urine creatinine analysis
vascular fluid filled catheter
whole body digital scale
wire myography using a Digi-Med tissue force analysis system with force transducer

Phenotype Annotations

decreased incidence of chemically-induced tumors (IED)

Phenotype Values via Phenominer

Options:

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Clinical Measurement

heart rate

left ventricle diastolic blood pressure

left ventricle systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricle developed pressure

red blood cell count

blood hemoglobin level

neutrophil granulocyte count

lymphocyte count

monocyte count

eosinophil granulocyte count

hematocrit (Hct)

mean corpuscular volume (MCV)

plasma anion gap

heart wet weight

heart weight as percentage of body weight

lung weight, dry/body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation (VE)

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin level (MCH)

mean corpuscular hemoglobin concentration (MCHC)

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

mammary tumor number

time to mammary tumor formation, post insult

serum total cholesterol level

total white blood cell count

total serum bilirubin level

blood pH

partial pressure of blood oxygen (Po2)

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine amino transferase (ALT) level

serum alkaline phosphatase level

serum aspartate amino transferase (AST) level

serum urea nitrogen level

serum globulin level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight as percentage of total heart left ventricle weight

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

methacholine median effective dose (ED50)

fractional change in blood vessel diameter per unit change in intravascular pressure

phenylephrine half maximal effective concentration (EC50)

phenylephrine Log half maximal effective concentration (Log EC50)

acetylcholine half maximal effective concentration (EC50)

acetylcholine Log half maximal effective concentration (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricle developed pressure

percent change in left ventricle systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine potassium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

References - curated

1.	Adamovic T, etal., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45.
2.	Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
3.	Kunert MP, etal., Physiol Genomics. 2006 Aug 16;26(3):218-25. Epub 2006 Jun 13.
4.	PhysGen strains

RGD Disease Portals

SS-Chr 19^BN/Mcwi has been annotated in the following RGD Disease Portals.

Cancer Phenotypes

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_drgs_chems	The aortic rings of animals on low-salt diet were less sensitive to phenylephrine and less sensitive to acetylcholine when on high salt-diet.	1598768
strain_life_disease	The blood pressure of females is 134 mmHg and of males is 123 mmHg.	629526
strain_other	The average weight of females is 178g and of males 271g.	629526
strain_reproduction	The average litter size is 7.8 pups and the average generation time is 50 days.	629526

More on this Strain
	Strain Nomenclature
	Strain Registration

RGD Object Information
RGD ID:	1358174
Created:	2005-05-13
Species:	Rattus norvegicus
Last Modified:	2009-06-15
Status:	ACTIVE

Strain: SS-Chr 19BN/Mcwi

Related Phenotype Data for Term "SS-Chr 19BN/Mcwi" (RS:0000800)

Strain: SS-Chr 19^BN/Mcwi