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Strain Registration

Strain: CDR/Ygl

Symbol: CDR/Ygl
Strain: CDR
Substrain: Ygl
RGD ID: 1357181
Citation ID: RRID:RGD_1357181
Ontology ID: RS:0000180
Also Known As: MDC-01-89; CDr/y
Type: inbred
Available Source: Not Available
Origination: Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel; Israeli Rat Genome Center, Ashkelon, Israel
Description: Cohen rats that had an oral tolerance test with blood glucose levels <180mg/dl were selected. More stringent criteria was set during the secondary inbreeding: rats with blood glucose levels <140mg/dl were selected. Brother and sister mating was carried on for 10 additional generations.
Last Known Status: Unknown





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
CDR/Ygl  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
blood glucose amount  EXP 2326163; 1626640 RGD 
blood insulin amount  EXP 1626640 RGD 
pancreas mass  EXP 2326163; 1626640 RGD 

Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. GENDER-SPECIFIC GENETIC DISSECTION OF DIABETES IN A RODENT MODEL IDENTIFIES ICA1 AND NDUFA4 AS MAJOR CANDIDATE GENES. Barkalifa R, etal., Physiol Genomics. 2010 Jun 8.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
4. The newly inbred cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences. Weksler-Zangen S, etal., Diabetes 2001 Nov;50(11):2521-9.
5. A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the development of diabetes in a rodent model. Yagil C, etal., Dis Model Mech. 2018 Nov 20;11(11). pii: dmm.036699. doi: 10.1242/dmm.036699.
6. Metabolic and genomic dissection of diabetes in the Cohen rat. Yagil C, etal., Physiol Genomics. 2007 Apr 24;29(2):181-92. Epub 2007 Jan 9.
7. Unmasking of proteinuria in the course of genetic dissection of nonproteinuric diabetic nephropathy. Yagil Y, etal., Physiol Genomics. 2014 Jan 1;46(1):29-38. doi: 10.1152/physiolgenomics.00133.2013. Epub 2013 Nov 5.

Region

Strain QTL Data
Symbol Name Trait
Gluco32 Glucose level QTL 32 blood glucose amount   (VT:0000188)    
Gluco33 Glucose level QTL 33 blood glucose amount   (VT:0000188)    
Gluco34 Glucose level QTL 34 blood glucose amount   (VT:0000188)    
Gluco61 Glucose level QTL 61 blood glucose amount   (VT:0000188)    
Gluco62 Glucose level QTL 62 blood glucose amount   (VT:0000188)    
Gluco63 Glucose level QTL 63 blood glucose amount   (VT:0000188)    
Insul22 Insulin level QTL 22 blood insulin amount   (VT:0001560)    
Pancm3 Pancreatic morphology QTL 3 pancreas mass   (VT:0010144)    
Pancm4 Pancreatic morphology QTL 4 pancreas mass   (VT:0010144)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Males that were fed the regular rat diet showed a 3 fold increase in their weight at 4-6 months whereas the males that were fed diabetogenic diet grew at the same rate. Females did not show difference in growth curves irrespective of diet. 1342468
strain_characteristics They are resistant to the diabetogenic diet (high-sucrose low-copper). 1342468
strain_characteristics Insulin levels were higher in animals that were fed diabetogenic diet than the ones fed regular diet. 1342468