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Strain Registration

Strain: FHH-Chr 1BN-Dusp5em1Mcwi

Symbol: FHH-Chr 1BN-Dusp5em1Mcwi
Strain: FHH-Chr 1BN-Dusp5em1
Substrain: Mcwi
RGD ID: 13451538
Citation ID: RRID:RGD_13451538
Ontology ID: N/A
Alleles: Dusp5em1Mcwi
Also Known As: FHH-Chr 1BN-Dusp5em1Mcwi; FHH-Chr 1^[BN]-Dusp5^[em1Mcwi]
Type: mutant
Available Source: Not Available
Description: This strain was produced by injecting ZFNs targeting the following sequence CAGGGCAGCCGC-CACtggcaGAAGCTGCGGGAGGA in exon 1 of the rat Dusp5 gene into FHH-Chr 1BN/Mcwi embryos. The resulting mutation is a 14 bp deletion and a 3 bp insertion between nucleotides 449 and 464 in Dusp5 mRNA that creates a frame shift mutation which is predicted to introduce a premature stop codon at amino acid 121.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21252,538,408 - 252,555,320RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01274,245,184 - 274,258,595RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01281,658,075 - 281,671,486RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41259,754,234 - 259,767,645RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. Fan F, etal., PLoS One. 2014 Nov 14;9(11):e112878. doi: 10.1371/journal.pone.0112878. eCollection 2014.

Region


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