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Strain Registration

Strain: HTG

Symbol: HTG
Strain: HTG
Full Name: Prague hypertriglyceridemic
RGD ID: 1302795
Citation ID: RRID:RGD_1302795
Ontology ID: RS:0000397
Also Known As: hHTG
Type: inbred
Available Source: Not Available
Origination: Institute of Physiology, Academy of Sciences Prague, Czech Republic
Description: These were originally derived from a colony of Wistar rats. Animals with high plasma triglyceride levels were selected as breeding pair and their offsprings used for further breeding.
Last Known Status: Unknown





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Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Mapping of genetic loci predisposing to hypertriglyceridaemia in the hereditary hypertriglyceridaemic rat: analysis of genetic association with related traits of the insulin resistance syndrome. Klimes I, etal., Diabetologia 2003 Mar;46(3):352-8.
2. Mapping of genetic determinants of the sympathoneural response to stress. Klimes I, etal., Physiol Genomics 2005 Jan 20;20(2):183-7. Epub 2004 Nov 16.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. The hypertriglyceridemic rat as a genetic model of hypertension and diabetes. Stolba P, etal., Life Sci 1992;51(10):733-40.
5. Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems. Ueno T, etal., J Mol Med 2003 Jan;81(1):51-60. Epub 2002 Nov 21.
6. Rat model of familial combined hyperlipidemia as a result of comparative mapping. Ueno T, etal., Physiol Genomics 2004 Mar 12;17(1):38-47. Epub 2004 Jan 6.
7. Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach. Ueno T, etal., Physiol Res 2003;52(6):689-700.

Region

Strain QTL Data
Symbol Name Trait
Bp251 Blood pressure QTL 251 arterial blood pressure trait   (VT:2000000)    
Bp252 Blood pressure QTL 252 arterial blood pressure trait   (VT:2000000)    
Bp253 Blood pressure QTL 253 arterial blood pressure trait   (VT:2000000)    
Bp254 Blood pressure QTL 254 arterial blood pressure trait   (VT:2000000)    
Bp255 Blood pressure QTL 255 arterial blood pressure trait   (VT:2000000)    
Bp259 Blood pressure QTL 259 arterial blood pressure trait   (VT:2000000)    
Bp260 Blood pressure QTL 260 arterial blood pressure trait   (VT:2000000)    
Bp261 Blood pressure QTL 261 arterial blood pressure trait   (VT:2000000)    
Bp262 Blood pressure QTL 262 arterial blood pressure trait   (VT:2000000)    
Bp263 Blood pressure QTL 263 arterial blood pressure trait   (VT:2000000)    
Bp264 Blood pressure QTL 264 arterial blood pressure trait   (VT:2000000)    
Bp265 Blood pressure QTL 265 arterial blood pressure trait   (VT:2000000)    
Bp266 Blood pressure QTL 266 arterial blood pressure trait   (VT:2000000)    
Bw112 Body weight QTL 112 body mass   (VT:0001259)    
Bw113 Body weight QTL 113 body mass   (VT:0001259)    
Bw114 Body weight QTL 114 body mass   (VT:0001259)    
Bw16 Body weight QTL 16 body mass   (VT:0001259)    
Bw47 Body weight QTL 47 body mass   (VT:0001259)    
Bw48 Body weight QTL 48 body mass   (VT:0001259)    
Bw49 Body weight QTL 49 body mass   (VT:0001259)    
Bw50 Body weight QTL 50 body mass   (VT:0001259)    
Bw51 Body weight QTL 51 body mass   (VT:0001259)    
Cm38 Cardiac mass QTL 38 heart mass   (VT:0007028)    
Cm39 Cardiac mass QTL 39 heart mass   (VT:0007028)    
Cm40 Cardiac mass QTL 40 heart mass   (VT:0007028)    
Cm41 Cardiac mass QTL 41 heart mass   (VT:0007028)    
Cm42 Cardiac mass QTL 42 heart mass   (VT:0007028)    
Kidm22 Kidney mass QTL 22 kidney mass   (VT:0002707)    
Kidm23 Kidney mass QTL 23 kidney mass   (VT:0002707)    
Kidm24 Kidney mass QTL 24 kidney mass   (VT:0002707)    
Kidm25 Kidney mass QTL 25 kidney mass   (VT:0002707)    
Kidm26 Kidney mass QTL 26 kidney mass   (VT:0002707)    
Kidm27 Kidney mass QTL 27 kidney mass   (VT:0002707)    
Kidm28 Kidney mass QTL 28 kidney mass   (VT:0002707)    
Scl19 Serum cholesterol QTL 19 blood cholesterol amount   (VT:0000180)    
Scl20 Serum cholesterol level QTL 20 blood cholesterol amount   (VT:0000180)    
Scl21 Serum cholesterol level QTL 21 blood cholesterol amount   (VT:0000180)    
Scl33 Serum cholesterol QTL 33 blood cholesterol amount   (VT:0000180)    
Scl34 Serum cholesterol QTL 34 blood cholesterol amount   (VT:0000180)    
Scl35 Serum cholesterol QTL 35 blood cholesterol amount   (VT:0000180)    
Scl36 Serum cholesterol QTL 36 blood cholesterol amount   (VT:0000180)    
Stl25 Serum triglyceride level QTL 25 blood triglyceride amount   (VT:0002644)    
Stl26 Serum triglyceride level QTL 26 blood triglyceride amount   (VT:0002644)    
Stl27 Serum triglyceride level QTL 27 blood triglyceride amount   (VT:0002644)    
Stl28 Serum triglyceride level QTL 28 blood triglyceride amount   (VT:0002644)    
Stl29 Serum triglyceride level QTL 29 blood triglyceride amount   (VT:0002644)    
Stl30 Serum triglyceride level QTL 30 blood triglyceride amount   (VT:0002644)    
Stl4 Serum triglyceride level QTL 4 blood triglyceride amount   (VT:0002644)    
Stl5 Serum triglyceride level QTL 5 blood triglyceride amount   (VT:0002644)    
Stl6 Serum triglyceride level QTL 6 blood triglyceride amount   (VT:0002644)    
Stresp6 Stress response QTL 6 blood norepinephrine amount   (VT:0005663)    
Stresp7 Stress response QTL 7 blood norepinephrine amount   (VT:0005663)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Males have higher plasma triglycerides and total cholesterol levels. 1299960
strain_life_disease These develop several features of metabolic syndrome such as hypertriglyceridemia ,hypertension, hyperinsulinemia, impared glucose tolerance, age-dependent changes of plasma total cholesterol which are similar features of human familial combined hyperlipidemia (FCHL). 1299960
strain_other These have higher systolic, diastolic and mean arterial pressures as compared to Lewis rats. 1299960
strain_other These have higher systolic, diastolic and mean arterial pressures as compared to Lewis rats. 1342424

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-04-07 HTG  Prague hypertriglyceridemic  hHTG    Data merged 737654 APPROVED