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Strain: HAA/FDSC

Symbol: HAA/FDSC
Strain: HAA
Substrain: FDSC
Full Name: Hatano High Avoidance
RGD ID: 1300432
Citation ID: RRID:RGD_1300432
Ontology ID: RS:0000388
Also Known As: mdc-02-11;Hatano High Avoidance; MDC-02-11; NBRP Rat No: 0242
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: Hatano Research Institute, Food and Drug Safety Center, Hadano, Kanagawa, Japan
Description: In 1985 two lines of Sprague-Dawley were selectively bred for their active shuttle-box avoidance task which is a device used for evaluating the effects of chemicals in pharmacological and toxicological studies and testing learning behavior of animals. These animals have a higher rate of avoidance response and showed little interindividual variation.
Inbred Generations: F20+
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Behavior





Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "HAA/FDSC" (RS:0000388)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Reproductive endocrinology in Hatano high- and low-avoidance rats during the estrous cycle. Asai S, etal., Endocrine 2002 Jul;18(2):161-6.
2. Differential responses of the hypothalamo-pituitary-adrenocortical axis to acute restraint stress in Hatano high- and low-avoidance rats. Asai S, etal., J Endocrinol 2004 Jun;181(3):515-20.
3. Maternal behavior, milk ejection, and plasma hormones in Hatano high- and low-avoidance rats. Ohta R, etal., Horm Behav 2002 Sep;42(2):116-25.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
7. Minor involvement of somatic growth in the onset of puberty of Hatano high- and low-avoidance rats. Shirota M, etal., Reproduction 2004 Mar;127(3):389-95.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Have a rapid pup retrieval response. 1300229
strain_characteristics Milk secretion is more than LAA rats. 1300228
strain_other ACTH and prolactin synthesis in the anterior pituitary was significantly higher than LAA under stress conditions which states that the response of hypothalamo-pituitary axis to acute restraint stress is greater in HAA as compared to LAA. 1300230
strain_phys_biochem The peak level of prolactin surge and the plasma concentration of progesterone are lower than the LAA rats. 1300227
strain_phys_biochem These have lighter pituitary glands and ovaries as compared to the LAA rats, whereas the uterine weights and adrenal gland weights are higher than the LAA rats. 1300227
strain_reproduction Shed a larger number of oocytes at first ovulation as compared to the LAA rats. 1300228
strain_reproduction Males were born lighter in weight bu tbecame heavier under biological dams and attained puberty at a younger age than LAA. 1300228
strain_reproduction HAA rats show a regular 4-day estrous cycle. The level of preovulatory luteinizing hormone (LH) surge level is significantly higher than the LAA rats on the day of proestrus. 1300227

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-15 HAA/FDSC  Hatano High Avoidance  HAA/FDSC  Hatano High Avoidance  Name updated 68913 APPROVED