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Strain Registration

Strain: SD-Nr1i2em1Sage Nr1i3em1Sage

Symbol: SD-Nr1i2em1Sage Nr1i3em1Sage
Strain: SD-Nr1i2em1 Nr1i3em1
Substrain: Sage
RGD ID: 12903270
Citation ID: RRID:RGD_12903270
Ontology ID: RS:0004430
Alleles: Nr1i2em1Sage;   Nr1i3em1Sage
Also Known As: TGRS9100; SD- NR1i2/NR1i3tm1sage; PXR/CAR Knockout Rat ; SD-Nr1i2 em1SageNr1i3 em1Sage; SD-Nr1i2^[em1Sage] Nr1i3^[em1Sage]
Type: mutant
Available Source: Horizon Discovery
Origination: Horizon Discovery
Description: This model contains two knockout genes, the 20-bp deletion within rat Nr1i2 and the ZFN-induced 10-bp deletion within rat Nr1i3 gene.
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2017-05-10)
Research Usage Xenobiotic Sensors
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,632,940 - 83,638,193RGD_MAPPER_PIPELINEmRatBN7.2
mRatBN7.21162,460,213 - 62,496,665RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01389,585,072 - 89,591,278RGD_MAPPER_PIPELINERnor6.0
Rnor_6.01165,022,100 - 65,058,546RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01167,024,185 - 67,060,494RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01394,211,961 - 94,218,143RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41387,104,241 - 87,108,563RGD_MAPPER_PIPELINERGSC3.4
RGSC_v3.41164,239,918 - 64,276,702RGD_MAPPER_PIPELINERGSC3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Data curation from Horizon Discovery Data curation from Horizon Discovery (https://www.horizondiscovery.com/)
2. Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats. Forbes KP, etal., Drug Metab Dispos. 2017 Oct;45(10):1068-1076. doi: 10.1124/dmd.117.075788. Epub 2017 Jul 17.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-14 SD-Nr1i2em1Sage Nr1i3em1Sage    SD-Nr1i2em1SageNr1i3em1Sage    Symbol updated 68687 APPROVED
2018-03-14 SD-Nr1i2em1Sage Nr1i3em1Sage    SD-Nr1i2em1SageNr1i3em1Sage    Symbol updated 68687 APPROVED
2018-03-14 SD-Nr1i2em1SageNr1i3em1Sage    SD-Nr1i2 em1SageNr1i3 em1Sage    Symbol updated 68687 APPROVED
2018-03-14 SD-Nr1i2em1SageNr1i3em1Sage    SD-Nr1i2 em1SageNr1i3 em1Sage    Symbol updated 68687 APPROVED
2017-05-10 SD-Nr1i2 em1SageNr1i3 em1Sage    SD-Nr1i2 em1SageNr1i3 em1SAGE    Symbol updated 68687 APPROVED
2017-05-10 SD-Nr1i2 em1SageNr1i3 em1Sage    SD-Nr1i2 em1SageNr1i3 em1SAGE    Symbol updated 68687 APPROVED
2017-05-10 SD-Nr1i2 em1SageNr1i3 em1SAGE    SD-Nr1i2 em1SageNr1i3 em1    Symbol updated 68687 APPROVED
2017-05-10 SD-Nr1i2 em1SageNr1i3 em1SAGE    SD-Nr1i2 em1SageNr1i3 em1    Symbol updated 68687 APPROVED