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Strain Registration

Strain: SD-Tg(LRRK2*R1441C)268Rwm

Symbol: SD-Tg(LRRK2*R1441C)268Rwm
Strain: SD-Tg(LRRK2*R1441C)268
Substrain: Rwm
RGD ID: 12738212
Citation ID: RRID:RRRC_00775
Ontology ID: RS:0004314
Alleles: LRRK2
Also Known As: LRRK2 268; SD-Tg(LRRK2R1441C)1Rwm
Type: transgenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: These rats were created using BAC constructs consisting of the entire 144kb human LRRK2 locus containing the R1441C mutation and fused to a YPet reporter tag.
Genetic Status: Hemizygous
Coat Color: White
Last Known Status: Cryopreserved Sperm (as of 2017-08-22)
Research Usage Parkinson's Disease






References

References - curated
# Reference Title Reference Citation
1. LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function. Sloan M, etal., Hum Mol Genet. 2016 Mar 1;25(5):951-63. doi: 10.1093/hmg/ddv628. Epub 2016 Jan 6.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-14 SD-Tg(LRRK2*R1441C)268Rwm    SD-Tg(LRRK2*R1441C)1Rwm    Symbol updated 68687 APPROVED
2018-05-14 SD-Tg(LRRK2*R1441C)268Rwm    SD-Tg(LRRK2*R1441C)1Rwm    Symbol updated 68687 APPROVED
2017-08-22 SD-Tg(LRRK2*R1441C)1Rwm    SD-Tg(LRRK2R1441C)1Rwm    Symbol updated 68687 APPROVED
2017-08-22 SD-Tg(LRRK2*R1441C)1Rwm    SD-Tg(LRRK2R1441C)1Rwm    Symbol updated 68687 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00775 RGD