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Strain Registration

Strain: SD-Cntnap2em1Sage

Symbol: SD-Cntnap2em1Sage
Strain: SD-Cntnap2em1
Substrain: Sage
RGD ID: 11568646
Citation ID: RRID:RGD_11568646
Ontology ID: RS:0004310
Alleles: Cntnap2em1Sage
Also Known As: SD-Cntnap2tm1Sage; TGRS8820; SD-Cntnap2em1Sage; SD-Cntnap2^[em1Sage]
Type: mutant
Available Source: Horizon Discovery
Origination: Horizon Discovery
Description: The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Met into Sprague Dawley embryos. The resulting mutation was a 5-bp deletion in exon 6 of Cntnap2. Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot.
Genetic Status: Heterozygous
Last Known Status: Live Animals (as of 2017-05-05)
Research Usage Autism Spectrum Disorders, Synaptic Plasticity, Language disorders
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2474,109,455 - 76,366,434RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0474,700,539 - 77,025,463RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04140,006,078 - 141,697,964RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4474,277,978 - 75,440,178RGD_MAPPER_PIPELINERGSC3.4





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References

References - curated
# Reference Title Reference Citation
1. Altered Blood Brain Barrier Permeability and Oxidative Stress in Cntnap2 Knockout Rat Model. Memis I, etal., J Clin Med. 2022 May 11;11(10). pii: jcm11102725. doi: 10.3390/jcm11102725.
2. Altered Auditory Processing, Filtering, and Reactivity in the Cntnap2 Knock-Out Rat Model for Neurodevelopmental Disorders. Scott KE, etal., J Neurosci. 2018 Oct 3;38(40):8588-8604. doi: 10.1523/JNEUROSCI.0759-18.2018. Epub 2018 Aug 20.
3. Cntnap2 Knockout Rats and Mice Exhibit Epileptiform Activity and Abnormal Sleep-Wake Physiology. Thomas AM, etal., Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw026.

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