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Strain Registration

Strain: F344-Ttnem2Sage

Symbol: F344-Ttnem2Sage
Strain: F344-Ttnem2
Substrain: Sage
RGD ID: 11565829
Citation ID: RRID:RGD_11565829
Ontology ID: RS:0004303
Alleles: Ttnem2Sage
Also Known As: TTNtvZ rat; F344-Ttnem2Sage; F344-Ttn^[em2Sage]
Type: mutant
Available Source: Not Available
Origination: Duke-National University of Singapore, Singapore
Description: These ZFN mutant rats were produced by injecting zinc finger nuclease targeting rat Ttn into F344 embryos. The zinc-finger nuclease mediated genome editing system created a deletion of exons 2-6 (5,286-bp deletion, coordinates 2,323-7,608) to introduce a frameshift (Rnor_5.0).
Last Known Status: Unknown (as of 2016-11-28)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2361,652,432 - 61,924,912RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0363,565,160 - 63,837,815RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0370,138,896 - 70,408,647RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4359,404,023 - 59,665,308RGD_MAPPER_PIPELINERGSC3.4





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References

References - curated
# Reference Title Reference Citation
1. Titin-truncating variants affect heart function in disease cohorts and the general population. Schafer S, etal., Nat Genet. 2016 Nov 21. doi: 10.1038/ng.3719.

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