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Strain: SS-Shc1em1Mcwi

Symbol: SS-Shc1em1Mcwi
Strain: SS-Shc1em1
Substrain: Mcwi
RGD ID: 11553862
Citation ID: RRID:RGD_11553862
Ontology ID: RS:0004231
Alleles: Shc1em1Mcwi
Also Known As: SS-p66Shcem1Mcwi; SS-Shc1em1Mcwi; SS-Shc1^[em1Mcwi]
Type: mutant
Available Source: Contact MCW rat distribution at mcwcustomrats@mcw.edu
Origination: MCW Gene Editing Rat Resource Center
Description: ZFN system was used to introduce a mutation in the Shc1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 14-bp deletion in Exon 2 of the Shc1 gene.
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,837,937 - 174,849,538RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02188,745,503 - 188,757,066RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02208,159,786 - 208,171,348RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42181,616,581 - 181,628,144RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

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Clinical Measurement
renal afferent arteriole diameter

References

References - curated
# Reference Title Reference Citation
1. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. Miller B, etal., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-18 SS-Shc1em1Mcwi    SS-p66Shcem1Mcwi    Symbol updated 68687 APPROVED
2016-10-18 SS-Shc1em1Mcwi    SS-p66Shcem1Mcwi    Symbol updated 68687 APPROVED