Strain: BBDR/Rhw
Symbol:
BBDR/Rhw
Strain:
BBDR
Substrain:
Rhw
Ontology ID:
RS:0000073
Alleles:
Tnfrsf1a
Type:
inbred
Source:
R. H. William Laboratory, University of Washington, Seattle, Washington
Origin:
S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 1 53 days of age after the first and 67 1 10 days of age after the 9th cycle.
Phenotype Annotations
Phenotype Annotations
References - curated
1.
Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2.
Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
3.
Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4.
Festing, MFW, Personal Communication Update, Feb-2000
5.
Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
6.
Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
7.
Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
8.
Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
9.
Kawahito Y, etal., Immunogenetics 1998 Oct;48(5):335-8
10.
Klaff LS, etal., Mamm Genome 1999 Sep;10(9):883-7
11.
Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
12.
Martin AM, etal., Diabetes 1999 Nov;48(11):2138-44
13.
Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
RGD Disease Portals
BBDR/Rhw has been annotated in the following RGD Disease Portals.
Region
Strain QTL Data
Symbol Name Trait Subtrait
Cia13 Collagen induced arthritis QTL 13
Joint/bone inflammation
arthritis severity
Cia15 Collagen induced arthritis QTL 15
Joint/bone inflammation
type II collagen induced
Cia16 Collagen induced arthritis QTL 16
Joint/bone inflammation
type II collagen induced
Cia17 Collagen induced arthritis QTL 17
Joint/bone inflammation
type II collagen induced
Cia18 Collagen induced arthritis QTL 18
Joint/bone inflammation
type II collagen induced
Cia19 Collagen induced arthritis QTL 19
Joint/bone inflammation
type II collagen induced
Cia6 Collagen induced arthritis QTL 6
Joint/bone inflammation
type II collagen induced
Cia7 Collagen induced arthritis QTL 7
Joint/bone inflammation
type II collagen induced
Ciaa4 CIA Autoantibody QTL 4
Anti-type II collagen autoantibody titer
Ciaa5 CIA Autoantibody QTL 5
Anti-type II collagen autoantibody titer
Iddm2 Insulin dependent diabetes mellitus QTL 2
Glucose level
insulin-dependent
Iddm3 Insulin dependent diabetes mellitus QTL 3
Glucose level
Additional Information
RGD Curation Notes
Note Type
Note
Reference
strain_characteristics
This strain is Diabetic Resistant.
61032
strain_reproduction
Average litter size at weaning 7.2 pups for the diabetic-resistant colonies.
61032
Nomenclature History
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2012-04-06
BBDR/Rhw
BBDR/Rhw
Name updated
853
APPROVED
2012-04-06
BBDR/Rhw
BBDR/Rhw
Name updated
853
APPROVED
2010-09-20
BBDR/Rhw
BBDR/Rhw
Name updated
853
APPROVED
2010-09-20
BBDR/Rhw
BBDR/Rhw
Name updated
853
APPROVED
RGD Object Information
RGD ID:
10003
Created:
2000-05-25
Species:
Rattus norvegicus
Last Modified:
2000-05-25
Status:
ACTIVE
Phenotype Annotations
