Curtiss and Dunning 1926 at the Columbia University Institute for Cancer Research. To Heston 1945 at F30, to National Institutes of Health 1950 at F41. Subsequent sublines from Dunning or NIH. Donated to RRRC from NIH Animal Genetic Resource Bank (NIHAGR)
Many tumours induced by ptaquiloside, a carcinogen in the bracken fern (Hirono et al 1987).Caffeine suppresses 2-acetylaminofluorine-induced hepatic tumours (Hosaka et al 1984). Effects of retinoids on tumours of the skin, prostate and endocrine pancreas studied by Ohshina et al(1985). Susceptible to the development of glioblastomas of a mixed oligo-astrocytic type following treatment with N-methyl-N-nitrosourea in the drinking water (Shibutani et al 1993). Like F344, refractory to the development of prostatic hyperplasia induced by citral compared with outbred Wistar and Sprague-Dawley rats (Scolnik et al 1994). Highly sensitive to the development of N-methyl-N-nitrosoguanidine (MNNG) induced gastric cancer though levels of adduct were same as in the resistant BUF strain (Sugimura et al 1995). Susceptible to the induction of tumours of the large intestine and forestomach by 1-hydroxyanthraquinone, though incidence can be reduced by the nonsteroidal anti-inflamatory drug indomethacin (Tanaka et al 1995). High hepatic metabolism of anilene in females (2/10) (Page and Vesell 1969). Absorbs diethylstilboestrol at intermediate rate, leading to a high incidence of mammary tumours (Dunning et al 1947, see also Rothschild et al 1987). High LD50 (120mg/kg) for pentobarbital sodium (1/7) (Shearer et al 1973). Long pentobarbitone sleeping time (1/10 males, 3/10 females), Vieregge et al (1987). Susceptible to the induction of gastric tumours by N-methyl-N-nitro-N- nitrosoguanidine (Ohgaki et al 1983).
Median survival 113 weeks in males, 108 weeks in females. Spontaneous tumours 46% testes,16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21%pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females.Other conditions include 28% of males and 20% of females with absent, hypoplastic or cystic kidneys on one side sometimes associated with an absent or defective uterine horn or atrophictestes on the same side (Maekawa and Odashima 1975). These abnormalities have a polygenic mode of inheritance (Cramer and Gill 1975). Spontaneous adenocarcinomas of ventral prostate seen in 7/41 untreated males at 34-37 months (Shain et al 1975, see also Ward et al 1980, Isaacs1984). This is substantially increased by a high fat diet (Kondo et al 1994). High survival to 2 years of age at 74% (rank 2/5) in males and 70% (rank 1/5) in females. However, a high incidence of relatively mild chronic renal disease and a high incidence of hydronephrosis and the congenital renal agenesis may make the strain unsuitable for long-term toxicological studies(Solleveld and Boorman 1986). Four spontaneous kidney and five bladder tumours found among a cohort of 300 rats maintained for 30 months (Vanmoorsellar et al 1993). Urolithiasis seen in 2/55 rats at an average age of 144 days (Kunstyr et al 1982). A diet deficientin choline and methionine has been used to develop a rat model of fatty liver transplantation (Teramoto et al 1993).
Almost free of spike-wave discharges associated with absence of epilepsy seen in strain WAG/Rij, while BN/Bi, B and G were intermediate (Inoue et al 1990). Low serum thyroxine (5/5) (Esber etal 1974). Low systolic blood pressure (17/17) (Hansen et al 1973). Low blood pressure (18/23), reaching 124_1.1 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Copper deficiency results in pigment patterns similar to that of the mottled mouse, a model for Menkes kinky hair syndrome (Miranda et al 1992). Liver gangliosides are of the a-type (cf LEA,LEW & BUF) (Kasai et al 1993)
Poor reproductive performance (9/12) and low litter size (11/12) (Hansen et al 1973). High (11%) early prenatal mortality (2/8) and high (10%) incidence of congenital malformations (Shoji 1977). High in-utero embryo mortality, which depends on maternal genotype (Cramer and Gill 1975).