RGD Reference Report - Expression of pituitary peptide 23 in the rat uterus: regulation by estradiol. - Rat Genome Database

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Expression of pituitary peptide 23 in the rat uterus: regulation by estradiol.

Authors: Chakraborty, C  Vrontakis, M  Molnar, P  Schroedter, IC  Katsumata, N  Murphy, LJ  Shiu, RP  Friesen, HG 
Citation: Chakraborty C, etal., Mol Cell Endocrinol. 1995 Feb 27;108(1-2):149-54.
RGD ID: 9831431
Pubmed: PMID:7758828   (View Abstract at PubMed)

Peptide 23 was first identified in pituitary cell conditioned medium as a secreted protein which was regulated in a similar fashion to growth hormone. It was subsequently found to be a member of the C-type lectin gene superfamily and identical to pancreatis associated protein (PAP). It is widely expressed in the gastrointestinal tract. Our present study demonstrates that peptide 23 gene is also expressed in the uterus. Peptide 23/PAP mRNA was at highest levels during estrus and was not detectable in the immature rat uterus. A single injection of 17 beta-estradiol resulted in a transient induction of peptide 23/PAP mRNA in ovariectomized rats whereas a sustained induction was seen with diethylstilbestrol implants. In situ hybridization localized peptide 23/PAP mRNA to the luminal epithelial cells. During gestation, peptide 23/PAP mRNA was detected only in the uterine samples from day 12 to 18 of pregnancy with maximal expression on day 12. Peptide 23 expression was confined to the uterus itself and not expressed in either the decidua or the fetal tissues. PSP/reg, another closely related member of the C-lectin gene family was not expressed in any of these uterine tissues. These results indicate that estrogen may act as a physiological regulator of peptide 23 in the uterus and suggests that this protein may have some role in estrogen action.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
estrous cycle  IEP 9831431 RGD 
female pregnancy  IEP 9831431 RGD 
response to estradiol  IEP 9831431 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Reg3b  (regenerating family member 3 beta)


Additional Information