RGD Reference Report - The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain. - Rat Genome Database

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The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain.

Authors: Puram, SV  Kim, AH  Park, HY  Anckar, J  Bonni, A 
Citation: Puram SV, etal., Cell Rep. 2013 Jul 11;4(1):19-30. doi: 10.1016/j.celrep.2013.06.006. Epub 2013 Jul 3.
RGD ID: 9686139
Pubmed: PMID:23831032   (View Abstract at PubMed)
PMCID: PMC4103748   (View Article at PubMed Central)
DOI: DOI:10.1016/j.celrep.2013.06.006   (Journal Full-text)

Proteasomes drive the selective degradation of protein substrates with covalently linked ubiquitin chains in eukaryotes. Although proteasomes are distributed throughout the cell, specific biological functions of the proteasome in distinct subcellular locales remain largely unknown. We report that proteasomes localized at the centrosome regulate the degradation of local ubiquitin conjugates in mammalian neurons. We find that the proteasomal subunit S5a/Rpn10, a ubiquitin receptor that selects substrates for degradation, is essential for proteasomal activity at centrosomes in neurons and thereby promotes the elaboration of dendrite arbors in the rodent brain in vivo. We also find that the helix-loop-helix protein Id1 disrupts the interaction of S5a/Rpn10 with the proteasomal lid and thereby inhibits centrosomal proteasome activity and dendrite elaboration in neurons. Together, our findings define a function for a specific pool of proteasomes at the neuronal centrosome and identify a biological function for S5a/Rpn10 in the mammalian brain.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of protein binding  IMP 9686139 RGD 
negative regulation of transcription by RNA polymerase II  IMP 9686139 RGD 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Id1  (inhibitor of DNA binding 1)
Psmd4  (proteasome 26S subunit ubiquitin receptor, non-ATPase 4)


Additional Information