RGD Reference Report - Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems. - Rat Genome Database

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Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems.

Authors: Gielen, AW  Lobell, A  Lidman, O  Khademi, M  Olsson, T  Piehl, F 
Citation: Gielen AW, etal., J Neuroimmunol. 2005 Jul;164(1-2):93-104.
RGD ID: 9686113
Pubmed: PMID:15913792   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2005.04.004   (Journal Full-text)

Expression of T cell immunoglobulin- and mucin-domain-containing molecules (TIMs) can be used as T helper (Th) differentiation markers in the human and mouse. We examined the expression of TIM-1 and -3 mRNAs in rat MBP(63-88)-induced experimental autoimmune encephalomyelitis (EAE). TIM-3 expression was upregulated in the spinal cord during EAE and following antigen restimulation of the encephalitogenic TCRBV8S2+ population. Interestingly, TIM-3 expression was also detected by in situ hybridization in resident cells of the nervous system. TIM-1 was expressed in B cells but not in resident CNS cells and TIM-1 mRNA levels in spinal cord were unchanged throughout the course of EAE. These results support the notion that TIM-3 can also be used as a Th1 differentiation marker in the rat. However, expression of TIM-1 and -3 is not restricted solely to T cells and the presence of TIM-3 in resident CNS cells may indicate a role for this molecule in the interaction between the nervous and immune systems.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Encephalomyelitis  ISOHavcr2 (Rattus norvegicus)9686113; 9686113mRNA:increased expression:spinal cord:RGD 
Experimental Autoimmune Encephalomyelitis  IEP 9686113mRNA:increased expression:spinal cord:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Havcr2  (hepatitis A virus cellular receptor 2)

Genes (Mus musculus)
Havcr2  (hepatitis A virus cellular receptor 2)

Genes (Homo sapiens)
HAVCR2  (hepatitis A virus cellular receptor 2)


Additional Information