RGD Reference Report - Growth inhibitory factor prevents degeneration of injured adult rat motoneurons. - Rat Genome Database

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Growth inhibitory factor prevents degeneration of injured adult rat motoneurons.

Authors: Sakamoto, T  Kawazoe, Y  Uchida, Y  Hozumi, I  Inuzuka, T  Watabe, K 
Citation: Sakamoto T, etal., Neuroreport. 2003 Dec 2;14(17):2147-51.
RGD ID: 9685806
Pubmed: PMID:14625437   (View Abstract at PubMed)
DOI: DOI:10.1097/01.wnr.0000095497.09138.24   (Journal Full-text)

We examined neuroprotective effects of growth inhibitory factor (GIF) on injured adult rat facial motoneurons. The right facial nerves of adult rats were avulsed and removed from the stylomastoid foramen, and an adenoviral vector encoding rat GIF and Myc epitope (AxCArGIFM) were injected into the facial canal. Animals treated with AxCArGIFM showed intense immunolabeling for GIF/Myc in injured facial motoneurons. Treatment with AxCArGIFM after avulsion significantly prevented the loss of injured facial motoneurons, improved choline acetyltransferase immunoreactivity and prevented the induction of nitric oxide synthase activity in these neurons. These results indicate that GIF may have therapeutic potential against degeneration of motoneurons in adult humans with motoneuron injury and motor neuron diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Facial Nerve Injuries treatmentISOMt3 (Rattus norvegicus)9685806; 9685806 RGD 
Facial Nerve Injuries treatmentIDA 9685806 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mt3  (metallothionein 3)

Genes (Mus musculus)
Mt3  (metallothionein 3)

Genes (Homo sapiens)
MT3  (metallothionein 3)


Additional Information