RGD Reference Report - Widespread expression of ecto-apyrase (CD39) in the central nervous system. - Rat Genome Database

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Widespread expression of ecto-apyrase (CD39) in the central nervous system.

Authors: Wang, TF  Guidotti, G 
Citation: Wang TF and Guidotti G, Brain Res. 1998 Apr 20;790(1-2):318-22.
RGD ID: 9685450
Pubmed: PMID:9593967   (View Abstract at PubMed)

We have shown that ecto-apyrase protein is expressed in primary neurons and astrocytes in cell culture (T.-F. Wang, P.A. Rosenberg, G. Guidotti, 1997. Mol. Brain Res. 1997, 47: 295-302). Here we present immunohistochemical studies showing that ecto-apyrase protein is widely distributed in rat brain, as it is present in neurons of the cerebral cortex, hippocampus and cerebellum as well as in glial cells and endothelial cells. Ecto-apyrase is enriched in brain postsynaptic density membrane fractions and is localized in proximity to synaptophysin, the marker of synaptic vesicles. These results together with the observation that P2 purinergic receptors are present throughout the brain suggest that ecto-apyrase is involved in regulating synaptic transmission mediated by extracellular ATP.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
synaptic vesicle  IDA 9685450 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Entpd1  (ectonucleoside triphosphate diphosphohydrolase 1)


Additional Information