RGD Reference Report - Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity. - Rat Genome Database

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Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity.

Authors: Watanabe, N  Ikeda, H  Nakamura, K  Ohkawa, R  Kume, Y  Tomiya, T  Tejima, K  Nishikawa, T  Arai, M  Yanase, M  Aoki, J  Arai, H  Omata, M  Fujiwara, K  Yatomi, Y 
Citation: Watanabe N, etal., Life Sci. 2007 Sep 1;81(12):1009-15. Epub 2007 Aug 19.
RGD ID: 9685426
Pubmed: PMID:17850827   (View Abstract at PubMed)
DOI: DOI:10.1016/j.lfs.2007.08.013   (Journal Full-text)

Lysophosphatidic acid (LPA) is a lipid mediator with multiple biological actions. We have reported that LPA stimulates hepatic stellate cell proliferation and inhibits DNA synthesis in hepatocytes, suggesting that LPA might play some role in the liver. We have found that plasma LPA level and serum autotaxin (ATX) activity were increased in patients with chronic hepatitis C. However, the clinical significance of LPA and its synthetic enzyme, autotaxin (ATX), is still unclear. To determine whether the increase of plasma LPA level and serum ATX activity might be found generally in liver injury, we examined the possible modulation of them in the blood in rats with various liver injuries. Plasma LPA level and serum ATX activity were increased in carbon tetrachloride-induced liver fibrosis correlatively with fibrosis grade, in dimethylnitrosamine-induced acute liver injury correlatively with serum alanine aminotransferase level or in 70% hepatectomy as early as 3 h after the operation. Plasma LPA level was correlated with serum ATX activity in rats with chronic and acute liver injury. ATX mRNA in the liver was not altered in carbon tetrachloride-induced liver fibrosis. Plasma LPA level and serum ATX activity are increased in various liver injuries in relation to their severity. Whether increased ATX and LPA in the blood in liver injury is simply a result or also a cause of the injury should be further clarified.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Chemical and Drug Induced Liver Injury  ISOEnpp2 (Rattus norvegicus)9685426; 9685426protein:increased activity:serum:RGD 
Chemical and Drug Induced Liver Injury  IEP 9685426protein:increased activity:serum:RGD 
Experimental Liver Cirrhosis  ISOEnpp2 (Rattus norvegicus)9685426; 9685426protein:increased activity:serum:RGD 
Experimental Liver Cirrhosis  IEP 9685426protein:increased activity:serum:RGD 
Liver Injury  ISOEnpp2 (Rattus norvegicus)9685426; 9685426protein:increased activity:serum:RGD 
Liver Injury  IEP 9685426protein:increased activity:serum:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Enpp2  (ectonucleotide pyrophosphatase/phosphodiesterase 2)

Genes (Mus musculus)
Enpp2  (ectonucleotide pyrophosphatase/phosphodiesterase 2)

Genes (Homo sapiens)
ENPP2  (ectonucleotide pyrophosphatase/phosphodiesterase 2)


Additional Information