RGD Reference Report - Epigenetic regulation of transcription by RNA polymerase III. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Epigenetic regulation of transcription by RNA polymerase III.

Authors: Bhargava, P 
Citation: Bhargava P Biochim Biophys Acta. 2013 Oct;1829(10):1015-25. doi: 10.1016/j.bbagrm.2013.05.005. Epub 2013 Jun 1.
RGD ID: 9685319
Pubmed: PMID:23732820   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbagrm.2013.05.005   (Journal Full-text)

Chromatin participates actively in all DNA transactions and all phenomena directly under the influence of chromatin are explained by epigenetic mechanisms. The genes transcribed by RNA polymerase (pol) III are generally found in regions free of nucleosomes, the structural units of chromatin. Yet, histone modifications and positions of nucleosomes in the gene flanking regions have been reported to show direct correlation with activity status of these genes. Gene-specific as well as genome-wide studies have also revealed association of several epigenetic components with pol III-transcribed genes. This review presents a summary of the research in past many years, which have gathered enough evidence to conclude that pol III-transcribed genes are important components of an epigenome.


Additional Information