RGD Reference Report - Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation. - Rat Genome Database

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Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation.

Authors: Millevoi, S  Vagner, S 
Citation: Millevoi S and Vagner S, Nucleic Acids Res. 2010 May;38(9):2757-74. doi: 10.1093/nar/gkp1176. Epub 2009 Dec 30.
RGD ID: 9684931
Pubmed: PMID:20044349   (View Abstract at PubMed)
PMCID: PMC2874999   (View Article at PubMed Central)
DOI: DOI:10.1093/nar/gkp1176   (Journal Full-text)

Messenger RNA (mRNA) 3' end formation is a nuclear process through which all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a poly(A) tail. This process, which consists in the recognition of defined poly(A) signals of the pre-mRNAs by a large cleavage/polyadenylation machinery, plays a critical role in gene expression. Indeed, the poly(A) tail of a mature mRNA is essential for its functions, including stability, translocation to the cytoplasm and translation. In addition, this process serves as a bridge in the network connecting the different transcription, capping, splicing and export machineries. It also participates in the quantitative and qualitative regulation of gene expression in a variety of biological processes through the selection of single or alternative poly(A) signals in transcription units. A large number of protein factors associates with this machinery to regulate the efficiency and specificity of this process and to mediate its interaction with other nuclear events. Here, we review the eukaryotic 3' end processing machineries as well as the comprehensive set of regulatory factors and discuss the different molecular mechanisms of 3' end processing regulation by proposing several overlapping models of regulation.


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