RGD Reference Report - Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer. - Rat Genome Database

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Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer.

Authors: Mascolo, M  Ilardi, G  Romano, MF  Celetti, A  Siano, M  Romano, S  Luise, C  Merolla, F  Rocco, A  Vecchione, ML  De Rosa, G  Staibano, S 
Citation: Mascolo M, etal., Histopathology. 2012 Dec;61(6):1089-105. doi: 10.1111/j.1365-2559.2012.04313.x. Epub 2012 Aug 8.
RGD ID: 9587477
Pubmed: PMID:22882088   (View Abstract at PubMed)
PMCID: PMC3546388   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1365-2559.2012.04313.x   (Journal Full-text)

AIMS: The natural history of oral squamous cell carcinomas (OSCCs) is variable and difficult to predict. This study aimed to assess the value of the expression of poly(ADP-ribose) polymerase 1 (PARP-1), chromatin assembly factor-1 (CAF-1)/p60 and the stem cell markers CD133, CD166, CD44, CD44v6 and nestin as markers of outcome and progression-free survival in OSCC patients. METHODS: Clinical data were collected from 66 patients (41 male and 25 female, aged 29-92 years) who underwent surgery for OSCC of the tongue, floor, lips, and palate. During follow-up (range: 12-131 months), 14 patients experienced relapse/metastasis and/or death. The study was performed by immunohistochemistry on paraffin-embedded tumour tissues, western blot analysis of tumour protein lysates and human cell lines, and RNA silencing assays. In addition, the human papillomavirus (HPV) status of primary tumours was evaluated by immunohistochemistry and viral subtyping. Univariate and multivariate analyses were performed to determine the correlation between these parameters and the clinical and pathological variables of the study population. RESULTS AND CONCLUSIONS: We found that a PARP-1(high) /CAF-1 p60(high) /nestin(high) phenotype characterized the OSCCs with the worst prognosis (all HPV-negative). This may be of benefit in clinical management, since radio-enhancing anti-PARP-1 and/or anti-CAF-1/p60 agents may allow radioresistance to be bypassed in the nestin-overexpressing, metastasizing OSCC cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Neoplastic Processes  IEP 9587477protein:increased expression::RGD 
Neoplastic Processes  ISOCHAF1B (Homo sapiens)9587477; 9587477protein:increased expression::RGD 
oral squamous cell carcinoma disease_progressionIEP 9587477protein:increased expression:mouth mucosa:RGD 
oral squamous cell carcinoma disease_progressionISOCHAF1B (Homo sapiens)9587477; 9587477protein:increased expression:mouth mucosa:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Chaf1b  (chromatin assembly factor 1 subunit B)

Genes (Mus musculus)
Chaf1b  (chromatin assembly factor 1, subunit B)

Genes (Homo sapiens)
CHAF1B  (chromatin assembly factor 1 subunit B)


Additional Information