RGD Reference Report - Interleukin-17A expression in patients with chronic rhinosinusitis and its relationship with clinical features. - Rat Genome Database

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Interleukin-17A expression in patients with chronic rhinosinusitis and its relationship with clinical features.

Authors: Hu, XD  Bao, YY  Zhou, SH  Yao, HT  Mao, JY  Ji, XX  Wu, XH 
Citation: Hu XD, etal., J Int Med Res. 2013 Jun;41(3):777-84. doi: 10.1177/0300060513478089. Epub 2013 Apr 18.
RGD ID: 8696039
Pubmed: PMID:23613503   (View Abstract at PubMed)
DOI: DOI:10.1177/0300060513478089   (Journal Full-text)

OBJECTIVE: To investigate the expression of interleukin (IL) 17A in Chinese patients with chronic rhinosinusitis (CRS) and analyse its correlation with clinical parameters. METHODS: Patients undergoing functional endoscopic sinus surgery and matched controls were included in this retrospective study. Clinical assessments (using a visual analogue scale of symptom severity, Johansson endoscopic score and Lund-Mackay computed tomography score) were performed preoperatively. Mucosal specimens were analysed for inflammatory infiltration and IL-17A expression, using immunohistochemistry. RESULTS: In total, 40 patients undergoing functional endoscopic sinus surgery and 16 controls were included in the study. IL-17A levels were significantly higher in tissues from patients with CRS (with or without nasal polyps) than in control tissues. In CRS, IL-17A expression tended to be higher in tissues with infiltrating neutrophils than in those with infiltrating eosinophils, but this difference was not significant. IL-17A expression in CRS was positively correlated with symptom severity, endoscopic findings and radiological appearance. CONCLUSIONS: Expression of IL-17A was higher in Chinese patients with CRS than in controls, and was associated with infiltrating inflammatory cells, symptom severity, endoscopic findings and radiological appearance. These findings suggest that IL-17A may play a role in CRS pathogenesis and remodelling of nasal polyps.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Chronic Rhinosinusitis  IEP 8696039protein:increased expression:uncinate process and nasal mucosa (human)RGD 
Chronic Rhinosinusitis  ISOIL17A (Homo sapiens)8696039; 8696039protein:increased expression:uncinate process and nasal mucosa (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il17a  (interleukin 17A)

Genes (Mus musculus)
Il17a  (interleukin 17A)

Genes (Homo sapiens)
IL17A  (interleukin 17A)


Additional Information