RGD Reference Report - Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene. - Rat Genome Database

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Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene.

Authors: Tanaka, S  Yamamoto, H  Takeuchi, S  Takeuchi, T 
Citation: Tanaka S, etal., Development. 1990 Feb;108(2):223-7.
RGD ID: 8694355
Pubmed: PMID:2112453   (View Abstract at PubMed)

We introduced a mouse tyrosinase minigene, mg-Tyrs-J, in which the authentic genomic 5' non-coding flanking sequence was fused to a mouse tyrosinase cDNA, into fertilized egges of albino mice. Of the 25 animals that developed from the injected eggs, four mice exhibited pigmented hair and eyes. Histological analysis of the transgenic mice revealed that the melanogenesis was restricted to hair bulbs and eyes. These results suggest that this minigene encodes active tyrosinase protein and that its 5' flanking region contains the sequences regulating expression of mouse tyrosinase gene. This is the first report of a successful expression of tyrosinase gene and of pigment production in transgenic mice.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Albinism treatmentISOTyr (Mus musculus)8694355; 8694355 RGD 
Albinism treatmentIMP 8694355 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tyr  (tyrosinase)

Genes (Mus musculus)
Tyr  (tyrosinase)

Genes (Homo sapiens)
TYR  (tyrosinase)


Additional Information