RGD Reference Report - Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock. - Rat Genome Database

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Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock.

Authors: Zhang, M  Wang, X  Wang, X  Hou, X  Teng, P  Jiang, Y  Zhang, L  Yang, X  Tian, J  Li, G  Cao, J  Xu, H  Li, Y  Wang, Y 
Citation: Zhang M, etal., Mol Med Rep. 2013 Apr;7(4):1293-9. doi: 10.3892/mmr.2013.1315. Epub 2013 Feb 8.
RGD ID: 8694329
Pubmed: PMID:23404057   (View Abstract at PubMed)
DOI: DOI:10.3892/mmr.2013.1315   (Journal Full-text)

Oxymatrine (OMT), an alkaloid extracted from Sophora japonica (kushen), is used to treat inflammatory diseases and various types of cancer in traditional Chinese medicine. However, the cellular and molecular mechanisms underlying the antiinflammatory activity of OMT remain poorly understood. The present study explored the protective effect of OMT on myocardial injury in rats with septic shock by inhibiting the activation of the janus kinasesignal transducer and activator of transcription (JAK/STAT) signaling pathway. OMT treatment was found to significantly inhibit the activation of JAK2 and STAT3 in myocardial tissue. It also attenuated the expression of proinflammatory cytokines, including interleukin1beta and tumor necrosis factoralpha. In addition, OMT exhibited antiinflammatory properties as heart function and myocardial contractility was improved and pathological and ultrastructural injury was prevented in myocardial tissue induced by septic shock. The results indicate that OMT exhibits substantial therapeutic potential for the treatment of septic shockinduced myocardial injury through inhibition of the JAK2/STAT3 signaling pathway.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
heart disease treatmentISOJak2 (Rattus norvegicus)8694329; 8694329associated with Shock and SepticRGD 
heart disease treatmentIEP 8694329; 8694329associated with Shock and SepticRGD 
heart disease treatmentISOStat3 (Rattus norvegicus)8694329; 8694329associated with Shock and SepticRGD 

Objects Annotated

Genes (Rattus norvegicus)
Jak2  (Janus kinase 2)
Stat3  (signal transducer and activator of transcription 3)

Genes (Mus musculus)
Jak2  (Janus kinase 2)
Stat3  (signal transducer and activator of transcription 3)

Genes (Homo sapiens)
JAK2  (Janus kinase 2)
STAT3  (signal transducer and activator of transcription 3)


Additional Information