RGD Reference Report - Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients. - Rat Genome Database

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Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients.

Authors: Filho, CB  Rodrigues, FF  Segat, L  Fonseca, AM  Araujo, J  Arahata, C  Pontes, L  Vilar, L  De Lima Filho, JL  Crovella, S 
Citation: Filho CB, etal., Int J Immunogenet. 2012 Aug;39(4):357-61. doi: 10.1111/j.1744-313X.2012.01102.x. Epub 2012 Feb 23.
RGD ID: 8693703
Pubmed: PMID:22360648   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1744-313X.2012.01102.x   (Journal Full-text)

We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autoimmune thyroiditis susceptibilityIAGP 8693703DNA:polymorphism:exon:RGD 
autoimmune thyroiditis susceptibilityISOMBL2 (Homo sapiens)8693703; 8693703DNA:polymorphism:exon:RGD 
Hashimoto Disease susceptibilityIAGP 8693703DNA:polymorphism:exon:RGD 
Hashimoto Disease susceptibilityISOMBL2 (Homo sapiens)8693703; 8693703DNA:polymorphism:exon:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information