RGD Reference Report - Estrogen aggravates iodoacetate-induced temporomandibular joint osteoarthritis. - Rat Genome Database

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Estrogen aggravates iodoacetate-induced temporomandibular joint osteoarthritis.

Authors: Wang, XD  Kou, XX  Meng, Z  Bi, RY  Liu, Y  Zhang, JN  Zhou, YH  Gan, YH 
Citation: Wang XD, etal., J Dent Res. 2013 Oct;92(10):918-24. doi: 10.1177/0022034513501323. Epub 2013 Aug 9.
RGD ID: 8663479
Pubmed: PMID:23934157   (View Abstract at PubMed)
DOI: DOI:10.1177/0022034513501323   (Journal Full-text)

Temporomandibular joint osteoarthritis (TMJOA) is clinically characterized by female preponderance, with a female-to-male ratio of more than 2:1; however, the underlying mechanism remains obscure. We examined the effects of estrogen on TMJOA induced by monosodium iodoacetate. Female rats were randomly and equally divided into 5 groups: control, sham-ovariectomized, and ovariectomized rats treated, respectively, with 17beta-estradiol (E2) at doses of 0 microg, 20 microg, and 80 microg/day until the end of the experiment. After induction of TMJOA, TMJs were evaluated by histopathology and microCT, and the expression of Fas, FasL, caspase 3, and caspase 8 was evaluated by real-time polymerase chain-reaction or immunohistochemistry. Another 5 groups of female rats were used to evaluate the effect of estrogen receptor antagonist ICI 182780 on E2 effects on TMJOA, when injected intraperitoneally into the control, sham-ovariectomized, and 80-microg-E2-treated groups. We found that E2 potentiated cartilage degradation and subchondral bone erosion in iodoacetate-induced TMJOA. E2 also potentiated mRNA expression of Fas, FasL, caspase 3, and caspase 8 in the condylar cartilage. Moreover, the estrogen receptor antagonist partially blocked E2 effects on TMJOA. These findings suggest that E2 could aggravate TMJOA, which may be an important mechanism underlying the sexual dimorphism of TMJOA.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Temporomandibular Joint Osteoarthritis  ISOFas (Rattus norvegicus)8663479; 8663479mRNA:increased expression:mandibular condyle and cartilage (rat)RGD 
Temporomandibular Joint Osteoarthritis  IEP 8663479mRNA:increased expression:mandibular condyle and cartilage (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fas  (Fas cell surface death receptor)

Genes (Mus musculus)
Fas  (Fas cell surface death receptor)

Genes (Homo sapiens)
FAS  (Fas cell surface death receptor)


Additional Information