RGD Reference Report - Increased intensities of fas expression on peripheral T-cell subsets in severe autoimmune thyroid disease. - Rat Genome Database

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Increased intensities of fas expression on peripheral T-cell subsets in severe autoimmune thyroid disease.

Authors: Maruoka, H  Watanabe, M  Matsuzuka, F  Takimoto, T  Miyauchi, A  Iwatani, Y 
Citation: Maruoka H, etal., Thyroid. 2004 Jun;14(6):417-23.
RGD ID: 8662824
Pubmed: PMID:15242568   (View Abstract at PubMed)
DOI: DOI:10.1089/105072504323150723   (Journal Full-text)

Fas (CD95)-Fas ligand (FasL; CD178)-induced apoptosis is necessary for the maintenance of self-tolerance. To clarify whether or not any abnormalities in the Fas-FasL system exist in patients with autoimmune thyroid disease (AITD), we examined the expression of Fas and FasL on peripheral T lymphocytes by three-color flow cytometry in 113 patients with AITD and 49 healthy controls. The intensities of Fas expression in both CD4(+) and CD8(+) T cells decreased in thyrotoxic patients with Graves' disease (GD), but increased in both patients with severe Hashimoto's disease (HD) undergoing treatment and seriously intractable patients with GD continuously positive for thyrotropin (TSH) receptor antibody despite treatment with antithyroid drugs for more than 5 years. The proportion of Fas expression was increased in CD4(+) T cells from patients with untreated GD, and in CD8(+) T cells from patients with severe HD. The proportion of CD8(+) T cells decreased in patients with severe HD. FasL were not expressed on T cells in controls and patients with AITD. These results indicate that (1). the intensities of Fas expression on peripheral T cells increase in severe autoimmune thyroid diseases and (2). both the intensity and the proportion of Fas expression may be important for the induction of apoptosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hashimoto Disease severityIEP 8662824protein:increased expression:peripheral blood and CD8-Positive T-Lymphocytes (human)RGD 
Hashimoto Disease severityISOFAS (Homo sapiens)8662824; 8662824protein:increased expression:peripheral blood and CD8-Positive T-Lymphocytes (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fas  (Fas cell surface death receptor)

Genes (Mus musculus)
Fas  (Fas cell surface death receptor)

Genes (Homo sapiens)
FAS  (Fas cell surface death receptor)


Additional Information