RGD Reference Report - Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus.

Authors: Hirota, M  Ito, T  Okudela, K  Kawabe, R  Yazawa, T  Hayashi, H  Nakatani, Y  Fujita, K  Kitamura, H 
Citation: Hirota M, etal., J Oral Pathol Med. 2002 Apr;31(4):204-12.
RGD ID: 8662419
Pubmed: PMID:12076323   (View Abstract at PubMed)

BACKGROUND: In oral lichen planus (OLP), destruction of the basal cell layer, which is one of the characteristic histological features, is seen and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium. METHODS: We studied mucosal tissues from 19 patients of OLP and 10 controls, with immunohistochemistry for Ki-67, p53, cyclin dependent kinase inhibitors (CDKI) and cyclins. Mitotic count was calculated. TUNEL assay was also performed for evaluation of apoptotic cell death. RESULTS: Mitotic count, Ki-67 and cyclin D1 labeling indices in the basal and parabasal layers of OLP mucosa were elevated in comparison with those of controls. p53, p21Cip1 and TUNEL indices of OLP mucosa were also increased. CONCLUSIONS: These complex changes, which concomitantly occur in the injured mucosal epithelium, could contribute to the development and maintenance of characteristic mucosal epithelial architectures seen in OLP.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Oral Lichen Planus  IEP 8662419protein:increased expression:mucosa:RGD 
Oral Lichen Planus  ISOCDKN1A (Homo sapiens)8662419; 8662419protein:increased expression:mucosa:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn1a  (cyclin-dependent kinase inhibitor 1A)

Genes (Mus musculus)
Cdkn1a  (cyclin dependent kinase inhibitor 1A)

Genes (Homo sapiens)
CDKN1A  (cyclin dependent kinase inhibitor 1A)


Additional Information