RGD Reference Report - p21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma. - Rat Genome Database

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p21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma.

Authors: Nemes, JA  Nemes, Z  Marton, IJ 
Citation: Nemes JA, etal., J Oral Pathol Med. 2005 May;34(5):274-9.
RGD ID: 8662374
Pubmed: PMID:15817070   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1600-0714.2005.00310.x   (Journal Full-text)

BACKGROUND: Previous research on the prognostic relevance of p21(WAF1/CIP1) in oral squamous cell carcinomas (OSCC) yielded inconclusive and contradictory data. OBJECTIVES: To investigate the prognostic significance of p21(WAF1/CIP1) expression, its relationship to p53 accumulation, proliferation-associated proteins Ki-67 and cyclin D1 in relation to survival and clinicopathological features in OSCC. METHODS: Surgical specimens taken from 106 randomly selected patients were studied by immunohistochemistry. Expression of the protein of interest was correlated with clinical data. RESULTS: p21(WAF1/CIP1) expression was found in 61.3% of OSCCs. Expression of p21(WAF1/CIP1) significantly correlated with tumor size (P = 0.005), lymph node involvement (P = 0.002), clinical stage (P < 0.001), and tumor site (P = 0.002). Patients with tumors showing p21(WAF1/CIP1) immunopositivity had decreased 2-year survival (P = 0.018). Expression of p21(WAF1/CIP1) was not related to age, gender, risk factors (tobacco, alcohol), dental status, or tumor differentiation grade. The p21(WAF1/CIP1) expression positively correlated with proliferation-related variables Ki-67 (P = 0.010) and cyclin D1 (P < 0.001), but not with p53 expression. CONCLUSIONS: The expression of p21(WAF1/CIP1) was found to be associated with poorer prognosis and tumor aggressivity in OSCC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Lymphatic Metastasis  IEP 8662374associated with Oral Squamous Cell CarcinomaRGD 
Lymphatic Metastasis  ISOCDKN1A (Homo sapiens)8662374; 8662374associated with Oral Squamous Cell CarcinomaRGD 
oral squamous cell carcinoma disease_progressionIEP 8662374 RGD 
oral squamous cell carcinoma disease_progressionISOCDKN1A (Homo sapiens)8662374; 8662374 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn1a  (cyclin-dependent kinase inhibitor 1A)

Genes (Mus musculus)
Cdkn1a  (cyclin dependent kinase inhibitor 1A)

Genes (Homo sapiens)
CDKN1A  (cyclin dependent kinase inhibitor 1A)


Additional Information